Tumor Microenvironment in Ovarian Cancer: Function and Therapeutic Strategy
| Autor: | Xia Zhao, Yanfei Yang, Jing Yang, Xiawei Wei, Yang Yang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
endocrine system anti-angiogenesis therapy endocrine system diseases medicine.medical_treatment Review medicine.disease_cause immune checkpoint inhibitors Transcriptome Cell and Developmental Biology 03 medical and health sciences 0302 clinical medicine medicine tumor microenvironment tumor-associated macrophage-targeted strategies In patient lcsh:QH301-705.5 Therapeutic strategy Tumor microenvironment Chemotherapy business.industry Cell Biology medicine.disease female genital diseases and pregnancy complications ovarian cancer 030104 developmental biology lcsh:Biology (General) 030220 oncology & carcinogenesis Cancer research Carcinogenesis Ovarian cancer business Function (biology) Developmental Biology |
| Zdroj: | Frontiers in Cell and Developmental Biology Frontiers in Cell and Developmental Biology, Vol 8 (2020) |
| ISSN: | 2296-634X |
| Popis: | Ovarian cancer is one of the leading causes of death in patients with gynecological malignancy. Despite optimal cytoreductive surgery and platinum-based chemotherapy, ovarian cancer disseminates and relapses frequently, with poor prognosis. Hence, it is urgent to find new targeted therapies for ovarian cancer. Recently, the tumor microenvironment has been reported to play a vital role in the tumorigenesis of ovarian cancer, especially with discoveries from genome-, transcriptome- and proteome-wide studies; thus tumor microenvironment may present potential therapeutic target for ovarian cancer. Here, we review the interactions between the tumor microenvironment and ovarian cancer and various therapies targeting the tumor environment. |
| Databáze: | OpenAIRE |
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