Size-tuneable and immunocompatible polymer nanocarriers for drug delivery in pancreatic cancer

Autor: Popov, Andrea Bistrović, Melle, Francesca, Linnane, Emily, González-López, Cristina, Ahmed, Ishtiaq, Parshad, Badri, Franck, Christoph O, Rahmoune, Hassan, Richards, Frances M, Muñoz-Espín, Daniel, Jodrell, Duncan I, Fairen-Jimenez, David, Fruk, Ljiljana
Přispěvatelé: Richards, Frances M [0000-0001-7947-7853], Fairen-Jimenez, David [0000-0002-5013-1194], Apollo - University of Cambridge Repository
Rok vydání: 2022
Předmět:
Zdroj: Nanoscale. 14(17)
ISSN: 2040-3372
Popis: Nanocarriers have emerged as one of the most promising approaches for drug delivery. Although several nanomaterials have been approved for clinical use, the translation from lab to clinic remains challenging. However, by implementing rational design strategies and using relevant models for their validation, these challenges are being addressed. This work describes the design of novel immunocompatible polymer nanocarriers made of melanin-mimetic polydopamine and Pluronic F127 units. The nanocarrier preparation was conducted under mild conditions, using a highly reproducible method that was tuned to provide a range of particle sizes (
Databáze: OpenAIRE