Glycosaminoglycans in Tendon Physiology, Pathophysiology, and Therapy
| Autor: | Christina N. M. Ryan, Dimitrios I. Zeugolis, Alex J Lomas, Anna Sorushanova, Abhay Pandit, Anne Maria Mullen |
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| Rok vydání: | 2015 |
| Předmět: |
Scaffold
Aging Biomaterial design Biomedical Engineering Pharmaceutical Science Physiology Bioengineering 02 engineering and technology Tendon tissue Regenerative Medicine Glycosaminoglycan Tendons 03 medical and health sciences Tendon Injuries medicine Animals Humans Regeneration 030304 developmental biology Glycosaminoglycans Pharmacology 0303 health sciences Tissue Scaffolds Chemistry Regeneration (biology) Organic Chemistry Abnormal expression 021001 nanoscience & nanotechnology Pathophysiology Tendon medicine.anatomical_structure 0210 nano-technology Biotechnology |
| Zdroj: | Bioconjugate chemistry. 26(7) |
| ISSN: | 1520-4812 |
| Popis: | Although glycosaminoglycans constitute a minor portion of native tissues, they play a crucial role in various physiological processes, while their abnormal expression is associated with numerous pathophysiologies. Glycosaminoglycans have become increasingly prevalent in biomaterial design for tendon repair, given their low immunogenicity and their inherent capacity to stimulate the regenerative processes, while maintaining resident cell phenotype and function. Further, their incorporation into three-dimensional scaffold conformations significantly improves their mechanical properties, while reducing the formation of peritendinous adhesions. Herein, we discuss the role of glycosaminoglycans in tendon physiology and pathophysiology and the advancements achieved to date using glycosaminoglycan-functionalized scaffolds for tendon repair and regeneration. It is evidenced that glycosaminoglycan functionalization has led to many improvements in tendon tissue engineering and it is anticipated to play a pivotal role in future reparative therapies. |
| Databáze: | OpenAIRE |
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