Microtubules gate tau condensation to spatially regulate microtubule functions

Autor: Jisoo S. Han, Tracy C. Tan, Sergi Simó, Dan W. Nowakowski, Aileen Lam, Richard J. McKenney, Ruensern Tan, Kassandra M. Ori-McKenney, Michael Vershinin
Rok vydání: 2019
Předmět:
Aging
Spastin
Swine
1.1 Normal biological development and functioning
Biophysics
tau Proteins
Neuroimaging
Neurodegenerative
Alzheimer's Disease
Fibril
Microtubules
Medical and Health Sciences
Article
Quantitative Biology::Subcellular Processes
Mice
03 medical and health sciences
0302 clinical medicine
Microtubule
mental disorders
Acquired Cognitive Impairment
Molecular motor
Animals
030304 developmental biology
Neurons
Quantitative Biology::Biomolecules
0303 health sciences
Chemistry
Extramural
Quantitative Biology::Molecular Networks
Condensation
Neurosciences
Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)
Cell Biology
Biological Sciences
Single Molecule Imaging
Brain Disorders
Cell biology
030220 oncology & carcinogenesis
Neurological
Common property
Dementia
Microtubule-Associated Proteins
030217 neurology & neurosurgery
Developmental Biology
Zdroj: Nature cell biology, vol 21, iss 9
Nature cell biology
ISSN: 1476-4679
1465-7392
Popis: Tau is an abundant microtubule-associated protein in neurons. Tau aggregation into insoluble fibrils is a hallmark of Alzheimer’s disease and other dementias, yet the physiological state of tau molecules within cells remains unclear. Using single molecule imaging, we directly observe that the microtubule lattice regulates reversible tau self-association, leading to dynamic condensation of tau molecules on the microtubule surface. Tau condensates form selectively permissible barriers, spatially regulating the activity of MT severing enzymes and the movement of molecular motors through their boundaries. We propose that reversible self-association of tau molecules, controlled by the microtubule, is an important mechanism of tau’s biological functions, and that oligomerization of tau is a common property shared between the physiological and disease forms of the molecule.One Sentence Summary:Reversible tau oligomerization regulates microtubule functions.
Databáze: OpenAIRE
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