Permanent Chemotherapy-Induced Alopecia in Patients with Breast Cancer: A 3-Year Prospective Cohort Study
| Autor: | Eun Kyung Choi, Juhee Cho, Seok Jin Nam, Ji Hye Park, Mario E. Lacouture, Jin Seok Ahn, Dong Youn Lee, Jeong Eon Lee, Young Hyuck Im, Eliseo Guallar, Im Ryung Kim, Hae Kwang Lee, Danbee Kang, Yeon Hee Park |
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| Rok vydání: | 2018 |
| Předmět: |
musculoskeletal diseases
Cancer Research medicine.medical_specialty medicine.medical_treatment Breast Neoplasms macromolecular substances Cohort Studies 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine medicine Humans Chemotherapy Prospective Studies Adverse effect Prospective cohort study skin and connective tissue diseases integumentary system business.industry Breast neoplasm Cohort Sequela Alopecia Middle Aged medicine.disease musculoskeletal system 3. Good health Regimen Hair loss Oncology Chemotherapy Adjuvant Symptom Management and Supportive Care 030220 oncology & carcinogenesis Female business |
| Zdroj: | The Oncologist |
| ISSN: | 1549-490X |
| Popis: | Chemotherapy‐induced alopecia is (CIA) considered temporary; however, some patients report persistent alopecia several years after chemotherapy. Long‐term prospective data on the incidence and impact of permanent CIA is scarce. This article reports the results of a study conducted to estimate the long‐term incidence of persistent CIA in a cohort of breast cancer patients with measurements of hair volume and density before and after chemotherapy. Background. Although chemotherapy‐induced alopecia (CIA) is considered temporary, some patients report persistent alopecia several years after chemotherapy. There is, however, a paucity of long‐term prospective data on the incidence and impact of permanent CIA (PCIA). The objective of our study was to estimate the long‐term incidence of PCIA in a cohort of patients with breast cancer whose hair volume and density were measured prior to chemotherapy and who were followed for 3 years after chemotherapy. Materials and Methods. Prospective cohort study of consecutive patients ≥18 years of age with postoperative diagnosis of stage I–III breast cancer expected to receive adjuvant chemotherapy at the outpatient breast cancer clinic at the Samsung Medical Center in Seoul, Korea, from February 2012 to July 2013 (n = 61). Objective hair density and thickness were measured using a noninvasive bioengineering device. Results. The proportion of participants who had PCIA at 6 months and 3 years was 39.5% and 42.3%, respectively. PCIA was characterized in most patients by incomplete hair regrowth. Patients who received a taxane‐based regimen were more likely to experience PCIA compared with patients with other types of chemotherapy. At a 3‐year follow‐up, hair thinning was the most common problem reported by study participants (75.0%), followed by reduced hair volume (53.9%), hair loss (34.6%), and gray hair (34.6%). Conclusion. PCIA is a common adverse event of breast cancer adjuvant cytotoxic chemotherapy. Clinicians should be aware of this distressing adverse event and develop supportive care strategies to counsel patients and minimize its impact on quality of life. Implications for Practice. Knowledge of permanent chemotherapy‐induced alopecia, an under‐reported adverse event, should lead to optimized pretherapy counseling, anticipatory coping techniques, and potential therapeutic strategies for this sequela of treatment. |
| Databáze: | OpenAIRE |
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