Association Between Circulating Osteogenic Progenitor Cells and Disability and Frailty in Older Persons: The Nepean Osteoporosis and Frailty Study
| Autor: | Christopher Vidal, Sandra Bermeo, Philip Chung, Gustavo Duque, Oddom Demontiero, Ahmed Al-Saedi, Izabella Pokorski, Derek Boersma, Steven Phu, Piumali Gunawardene, Pushpa Suriyaarachchi |
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| Rok vydání: | 2015 |
| Předmět: |
Male
0301 basic medicine Sarcopenia Aging medicine.medical_specialty Cross-sectional study Frail Elderly Osteoporosis Logistic regression Sensitivity and Specificity Severity of Illness Index Disability Evaluation 03 medical and health sciences Predictive Value of Tests Internal medicine Severity of illness Prevalence medicine Humans Geriatric Assessment Aged Aged 80 and over Osteoblasts business.industry Stem Cells Australia Odds ratio medicine.disease humanities Confidence interval Cross-Sectional Studies 030104 developmental biology Quartile Disease Progression Female Independent Living Geriatrics and Gerontology business Biomarkers |
| Zdroj: | The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 71:1124-1130 |
| ISSN: | 1758-535X 1079-5006 |
| Popis: | Circulating osteogenic progenitor (COP) cells are considered as surrogates of the mesenchymal repository in the body. In this study, we hypothesized that COP cells decrease with age and that lower levels of COP cells are associated with greater frailty and disability in older persons. Using well-established clinical criteria, we quantified physical performance and disability and stratified frailty in a random sample of community-dwelling individuals enrolled in the Nepean Osteoporosis and Frailty (NOF) Study (mean age 82.8; N = 77; 70% female; 27 nonfrail, 23 prefrail, and 27 frail). Percentage of COP cells was quantified by flow cytometry. Logistic regression models estimated the relationship between the percentage of COP cells and prevalent disability, poor physical performance, and frailty. We found that aging is associated with a significant decrease in COP cells (p < .001). Lower percentages of COP cells were associated with disability and poor physical performance (p < .001). Older adults with COP cells in the lower quartile were more likely to be frail (odds ratio 2.65, 95% confidence interval 2.72-3.15, p < .001). In conclusion, COP cells in the circulation decrease with age. Lower percentages of COP cells in late life are associated with prevalent frailty and disability. Further longitudinal studies are needed to understand COP cells as a risk stratifier, biomarker, or therapeutic target and to predict disability in frail older persons. |
| Databáze: | OpenAIRE |
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