Hypervolemia does not cause degradation of the endothelial glycocalyx layer during open hysterectomy performed under sevoflurane or propofol anesthesia
| Autor: | Robert G. Hahn, Stelia Ntika, Janis Nemme, Camilla Krizhanovskii, Olegs Sabelnikovs, Indulis Vanags |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Ringer's Lactate Water-Electrolyte Imbalance Glycocalyx Hysterectomy Sevoflurane 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Natriuretic Peptide Brain medicine Humans 030212 general & internal medicine Propofol business.industry Albumin 030208 emergency & critical care medicine General Medicine Heparan sulfate Middle Aged medicine.disease Brain natriuretic peptide Latvia Anesthesiology and Pain Medicine chemistry Anesthesia Anesthetics Inhalation Fluid Therapy Female Hemoglobin Endothelium Vascular Heparitin Sulfate Syndecan-1 business Hypervolemia Anesthetics Intravenous medicine.drug |
| Zdroj: | Acta anaesthesiologica ScandinavicaREFERENCES. 64(4) |
| ISSN: | 1399-6576 |
| Popis: | BACKGROUND Fluid-induced hypervolemia may stimulate the release of natriuretic peptides and cause degradation (shedding) of the endothelial glycocalyx layer. Sevoflurane is believed to protect the glycocalyx, but the importance of using sevoflurane to prevent shedding during routine surgery is unclear. METHODS The plasma concentrations of brain natriuretic peptide and two biomarkers of glycocalyx shedding, syndecan-1, and heparan sulfate, were measured in 26 patients randomized to receive general anesthesia with sevoflurane or propofol during open abdominal hysterectomy. The fluid therapy consisted of 25 mL/kg (approximately 2 L) of Ringer´s lactate over 30 minutes. Blood hemoglobin and plasma albumin were used to indicate plasma volume expansion and capillary leakage. RESULTS The plasma concentrations of brain natriuretic peptide and shedding products showed low levels throughout the surgery (median brain natriuretic peptide, 21 ng/L; syndecan-1, 12.9 ng/mL; and heparan sulfate, 6.5 µg/mL), but the heparan sulfate concentration increased 2 hours post-operatively (to 17.3 µg/mL, P |
| Databáze: | OpenAIRE |
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