Effect of a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on arterial compliance and distensibility in patients with mild-to-moderate chronic kidney disease
| Autor: | Susanna J.E. Veringa, Irene L Vegting, Frans J. van Ittersum, Prabath W. B. Nanayakkara, Yvo M. Smulders, Coen D.A. Stehouwer, Piet M. ter Wee, Coen van Guldener |
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| Přispěvatelé: | Interne Geneeskunde, MUMC+: MA Interne Geneeskunde (3), RS: CARIM School for Cardiovascular Diseases, Pediatric surgery, Internal medicine, Nephrology, ICaR - Circulation and metabolism |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Homocysteine Brachial Artery Carotid Artery Common medicine.medical_treatment Urology law.invention chemistry.chemical_compound Vascular Stiffness Randomized controlled trial Double-Blind Method law cardiovascular disease medicine.artery medicine Humans Vitamin E Common carotid artery Brachial artery Aged Pravastatin business.industry General Medicine Middle Aged medicine.disease Femoral Artery arterial stiffness chemistry Nephrology Chronic Disease Arterial stiffness Female Kidney Diseases Hydroxymethylglutaryl-CoA Reductase Inhibitors business chronic kidney disease Kidney disease medicine.drug |
| Zdroj: | Clinical Nephrology, 78(4), 263-272. Dustri-Verlag Dr. Karl Feistle Veringa, S J, Nanayakkara, P W B, van Ittersum, F J, Vegting, I L, van Guldener, C, Smulders, Y M, ter Wee, P M & Stehouwer, C D A 2012, ' Effect of a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on arterial compliance and distensibility in patients with mild-to-moderate chronic kidney disease ', Clinical Nephrology, vol. 78, no. 4, pp. 263-272 . https://doi.org/10.5414/CN107439 |
| ISSN: | 0301-0430 |
| DOI: | 10.5414/CN107439 |
| Popis: | Background: Arterial stiffness is increased in chronic kidney disease (CKD). Intervention studies aimed at reduction of arterial stiffness in dialysis patients have been disappointing. We therefore investigated the effect of pravastatin, vitamin E, and homocysteine lowering on arterial compliance and distensibility coefficients in mild-to-moderate CKD. Methods: This is a sub-study of the ATIC study, a randomized, double-blind trial in 93 CKD patients. The treatment group received pravastatin to which vitamin E supplementation was added after 6 months and homocysteine lowering therapy after another 6 months. Measurement of the distensibility coefficient (DC) and the compliance coefficient (CC) of the common carotid (CCA), femoral (FA) and brachial artery (BA) was performed at 0, 6, 12, 18 months. Young's elastic modulus (YEM) was measured in the common carotid artery. Results: After 18 months, CCA-DC increased from mean (SD) 15.15 (6.67) to 16.52 (6.37) x 10(-3)kPa(-1) in the treatment and decreased from 18.44 (8.19) to 16.26 (7.35) in the placebo group (p = 0.057). CCA-CC increased from 0.64 (0.24) to 0.71 (0.26) mm(2)kPa(-1) in the treatment and decreased from 0.77 (0.28) to 0.69 (0.25) in the placebo group (p |
| Databáze: | OpenAIRE |
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