Mycobacterium Kansasii infection in a psoriasis patient treated with adalimumab and switch to apremilast: first report and literature review
| Autor: | Cesare Massone, Sanja Javor, Alexandra Maria Giovanna Brunasso, Emanuele Pontali, Simona Sola |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
business.industry Adalimumab Mycobacteria Case Report Dermatology QuantiFeron Tb Gold Test RL1-803 Mycobacterium kansasii Medicine Psoriasis patient Psoriasis Apremilast MYCOBACTERIUM KANSASII INFECTION business skin and connective tissue diseases medicine.drug psoriasis adalimumab QuantiFeron Tb Gold Test mycobacteria Mycobacterium Kansasii |
| Zdroj: | Dermatology Reports (2021) Dermatology Reports |
| Popis: | Patient under anti-TNF-alpha treatment have an increased risk of mycobacterial infections, particularly tuberculosis. Only four case reports of Mycobacterium kansasii infection under anti-TNF-α treatment (two with etanercept, two with infliximab) have been reported, but none under adalimumab. A 72-year-old man treated with adalimumab for psoriasis vulgaris and arthropathic psoriasis, complained on nocturnal cough, occasional hemoptysis and the new onset of ill-defined, reddish, asymptomatic persistent plaquesnodules covered by serum crusts on his back, on the dorsum of the right hand and right middle finger. Routine laboratory investigations, HIV and TB screening (QuantiFERONTB- Gold test) were all within normal limits. A skin biopsy was inconclusive and special stainings resulted negative for microorganisms. Only PCR identified M. kansasii. The patient stopped adalimumab and started anti-TB treatment with gradual improvement of the skin lesions. At 26 months follow-up visit no signs or symptoms of relapse of M. kansasii disease occurred. |
| Databáze: | OpenAIRE |
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