Hemophagocytic syndrome in a pancytopenic simian retrovirus-infected male rhesus macaque (Macaca mulatta)
| Autor: | T. M. Cotroneo, Lesley A. Colby, Ingrid L. Bergin |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
Pathology medicine.medical_specialty Anemia Pancytopenia Biology Simian Neutropenia Polymerase Chain Reaction Lymphohistiocytosis Hemophagocytic Simian retrovirus Bone Marrow Euthanasia Animal hemic and lymphatic diseases medicine Animals Humans General Veterinary Macrophages Monkey Diseases medicine.disease biology.organism_classification Immunohistochemistry Macaca mulatta Hypoplasia Retroviruses Simian Rhesus macaque Tumor Virus Infections medicine.anatomical_structure Immunology Bone marrow Autopsy Spleen Retroviridae Infections |
| Zdroj: | Veterinary pathology. 48(6) |
| ISSN: | 1544-2217 |
| Popis: | Hemophagocytic syndrome (HPS) is a macrophage hyperactivation disorder triggered by disrupted T–cell macrophage cytokine interaction. HPS has been reported in humans, dogs, cats, and cattle, and it is infrequent and poorly characterized in animals. A 16-year-old male rhesus macaque was euthanized because of severe pancytopenia, including nonregenerative anemia (hematocrit = 5.5%), neutropenia (0.29 K/μl), and thrombocytopenia (21 K/μl). Bone marrow was hypocellular with normal maturation, myeloid hypoplasia, and few megakaryocytes. There were numerous morphologically normal macrophages (12% of nucleated cells), with 6% of nucleated cells being hemophagocytic macrophages in the bone marrow. Serology was negative, but polymerase chain reaction and immunohistochemistry were positive for simian retrovirus type 2. Blood and bone marrow findings were consistent with HPS. Cytopenias are common in simian retrovirus–infected macaques, but HPS has not been reported. An association between simian retrovirus infection and HPS is undetermined, but retrovirus-associated HPS has been observed in humans. |
| Databáze: | OpenAIRE |
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