Parathyroid carcinoma in chronic renal disease – a case series of three patients and review of literature
| Autor: | Dusko Dundjerovic, Milan Jovanović, Jasna Trbojevic Stankovic, Dejan Stojakov, Matija Buzejić, Vladan Zivaljevic, Nikola Slijepcevic, Rastko Zivic, Ivan Paunovic |
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| Rok vydání: | 2021 |
| Předmět: |
Parathyroidectomy
medicine.medical_specialty business.industry medicine.medical_treatment 030232 urology & nephrology General Medicine Disease Chronic renal disease medicine.disease 3. Good health Surgery End stage renal disease Pathogenesis 03 medical and health sciences 0302 clinical medicine Parathyroid carcinoma 030220 oncology & carcinogenesis Medicine In patient Secondary hyperparathyroidism business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Acta Chirurgica Belgica. 123:199-206 |
| ISSN: | 2577-0160 0001-5458 |
| DOI: | 10.1080/00015458.2021.1970438 |
| Popis: | Background Apart from being a rare endocrine tumor, parathyroid carcinoma is also one of the rarest malignancies in human beings. Parathyroid carcinoma is even more uncommon in haemodialysis patients with end-stage renal disease. The pathogenesis of parathyroid hyperplasia in haemodialysis patients is well known, but the mechanism of development of parathyroid carcinoma in these patients remains unclear. Methods Three cases of parathyroid carcinoma in haemodialysis patients are presented in this study: a 69-year-old male patient and two female patients (67 and 61 years old). In all cases parathyroid carcinoma infiltrated the ipsilateral thyroid lobe and in one patient the right laryngeal nerve was involved as well. One patient underwent three surgical procedures. Results After surgical treatment, all patients were normocalcaemic and showed a significant reduction in PTH levels. Conclusion In patients with secondary hyperparathyroidism, who develop parathyroid carcinoma, surgical resection is the only viable treatment option. |
| Databáze: | OpenAIRE |
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