Clinical characteristics of patients with multiple sclerosis enrolled in a new registry in Egypt
| Autor: | Mohamed M. Fouad, Mahmoud S. Swelam, Mohsen Gadallah, Mai F. Fahmy, Hany Aref, Magd Zakaria, Mohamed A. Abdel Hafeez, Azza Abdel Nasser, Dina A. Zamzam, Ayman Abdel Hady, Shaimaa S. Khater |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Pediatrics Multiple Sclerosis Adolescent Disease Tertiary Care Centers Disability Evaluation Young Adult 03 medical and health sciences Sex Factors 0302 clinical medicine Epidemiology medicine Humans Medical history Registries Age of Onset Child Expanded Disability Status Scale business.industry Multiple sclerosis Clinical course General Medicine Middle Aged University hospital medicine.disease Cross-Sectional Studies 030104 developmental biology Neurology Egypt Female Neurology (clinical) Presentation (obstetrics) business 030217 neurology & neurosurgery |
| Zdroj: | Multiple Sclerosis and Related Disorders. 10:30-35 |
| ISSN: | 2211-0348 |
| DOI: | 10.1016/j.msard.2016.06.013 |
| Popis: | Background Epidemiological studies of multiple sclerosis (MS) are lacking in Egypt. Objective To study the characteristics of Egyptian patients with multiple sclerosis in a new registry in a major tertiary referral centre in Cairo, Egypt. Subject and methods Patients were from the project MS database of the Multiple Sclerosis Unit at Ain Shams University Hospitals (N=950). We conducted a detailed medical history and examination including the Expanded Disability Status Scale (EDSS). Results Females represented 72% of subjects (female: male ratio 2.57:1). The mean age of disease onset was 26.1±7.6 years. Relapsing-remitting MS (RRMS) was the most common presentation (74.6%). Visual or sensory symptoms were the most common at presentation with RRMS, while motor symptoms were the most common presentation in other types of MS. Time to diagnosis was delayed up to 2 years in 27.8% of patients. The mean EDSS score was 3.6±2.1; 55% had EDSS≤3. About half (49%) received a disease-modifying drug. Progressive MS and motor presentation were associated with higher disability. Conclusions This is the first documented MS registry from Egypt. The clinical characteristics of MS in Egypt was similar to other Arab countries and western countries. MS is more common among females in Egypt, with RRMS being the most common presentation. Visual symptoms and motor symptoms were the most common presentations in RRMS and progressive MS, respectively. Our findings also highlight the value of establishing registries in Egypt in order to be able to study, prospectively, the clinical course of the disease, the response to various DMD's and the epidemiology of MS in Egypt. |
| Databáze: | OpenAIRE |
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