Vitamin K2 suppresses malignancy of HuH7 hepatoma cells via inhibition of connexin 43
| Autor: | Ikuo Morita, Makoto Kaneda, Shigeki Arii, Rajib Bhattacharjee, Ken-ichi Nakahama, Dan Zhang |
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| Rok vydání: | 2008 |
| Předmět: |
Cancer Research
Carcinoma Hepatocellular Connexin Biology Connexins Cell Line Tumor medicine Humans Promoter Regions Genetic education DNA Primers education.field_of_study Base Sequence Liver Neoplasms Vitamin K2 Gap junction Vitamin K 2 Immunohistochemistry Molecular biology Cell biology medicine.anatomical_structure Oncology Cell culture Hepatocyte Connexin 32 sense organs Intracellular |
| Zdroj: | Cancer Letters. 263:53-60 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/j.canlet.2007.12.019 |
| Popis: | The anti-cancer potential of vitamin K(2) (VK(2)) in hepatoma has gained considerable attention but the underlying mechanisms are unclear. Treatment of HuH7 hepatoma cells with VK(2) produced a normal liver phenotype. Following treatment of cells with VK(2), there was an increase in gap junctional intercellular communication activity, accompanied by up-regulation of connexin 32 (Cx32), dominantly expressed in normal hepatocyte. In contrast, Cx43 expression was inhibited. Moreover, the effect of VK(2) on Cx32 was abolished by over-expression of Cx43. Taken together, we propose that the anti-tumor effect of VK(2) is at least partly due to a decrease in Cx43 promoter activity. |
| Databáze: | OpenAIRE |
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