Intracisternal TRH and RX 77368 potently activate gastric vagal efferent discharge in rats
| Autor: | Jen Yu Wei, T.J O-Lee, Yvette Taché |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Long lasting
Male medicine.medical_specialty Vagal stimulation Physiology Efferent Saline injection Thyrotropin-releasing hormone Biochemistry Efferent Pathways Injections Rats Sprague-Dawley Cellular and Molecular Neuroscience Endocrinology Internal medicine Cisterna Magna Medicine Animals Evoked Potentials Thyrotropin-Releasing Hormone Analysis of Variance business.industry Low dose Stomach Vagus Nerve Pyrrolidonecarboxylic Acid Rats Spinal Cord Gastric Mucosa Rat Stomach business |
| Zdroj: | Peptides. 18(2) |
| ISSN: | 0196-9781 |
| Popis: | O-Lee, T. J., J. Y. Wei and Y. TachE. Intracisternal Trh and Rx 77368 potently activate gastric vagal efferent discharge in rats. Peptides 18(2) 213–219, 1997.—The influence of intracisternal (ic) TRH and the stable TRH analog, RX 77368, on gastric vagal efferent discharge (GVED) was investigated in urethane-anesthetized rats. Consecutive IC injections of TRH (3, 30, and 300 ng) at 60 min intervals stimulated dose dependently multi-unit GVED with a peak increase of 90 ± 21%, 127 ± 18% and 145 ± 16% respectively. In two separate studies, IC injection of RX 77368 at 1.5 or 15 ng stimulated multi-unit GVED by 142 ± 24% and 244 ± 95% respectively. Saline injection IC had no effect on GVED. RX 77368 (1.5 ng, ic) action was long lasting (84 ± 13 min) compared with TRH (3 ng: 44 ± 7 min). Single-unit analysis also showed that 13 of 13 units responded to ic RX 77368 (1.5 ng) by an increase in activity. These data indicate that low doses of TRH injected ic stimulate vagal efferent outflow to the rat stomach and that RX 77368 action is more potent than TRH. |
| Databáze: | OpenAIRE |
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