Incidence of Diabetes Mellitus and Associated Risk Factors in the Adult Population of the Basque Country, Spain
| Autor: | Eunate Arana, Alicia Martín-Nieto, J Oriol Casanovas-Marsal, Sonia Gaztambide, Elsa Fernandez-Rubio, Rosa de Diego Martínez, Juan Del Olmo, Luis Castaño, Inés Urrutia, Anibal Aguayo |
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| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
Male obesity 030204 cardiovascular system & hematology 0302 clinical medicine Endocrinology Risk Factors Medicine Cumulative incidence Prediabetes Family history glucose Aged 80 and over Multidisciplinary Incidence (epidemiology) Middle Aged Cardiovascular Diseases Cohort Hypertension Female individuals Adult Adolescent complications Science prevalence 030209 endocrinology & metabolism Article type-2 Diabetes Complications Prediabetic State 03 medical and health sciences Young Adult Insulin resistance Medical research Diabetes mellitus Diabetes Mellitus Humans definition Aged disease business.industry Waist-Hip Ratio Health care Glucose Tolerance Test medicine.disease Obesity life-style interventions Spain Insulin Resistance business Demography |
| Zdroj: | Addi. Archivo Digital para la Docencia y la Investigación instname Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021) Scientific Reports Addi: Archivo Digital para la Docencia y la Investigación Universidad del País Vasco |
| Popis: | The aim of this study was to estimate the incidence of diabetes mellitus in the Basque Country and the risk factors involved in the disease by reassessing an adult population after 7 years of follow-up. In the previous prevalence study, 847 people older than 18 years were randomly selected from all over the Basque Country and were invited to answer a medical questionnaire, followed by a physical examination and an oral glucose tolerance test. In the reassessment, the same variables were collected and the resulting cohort comprised 517 individuals of whom 43 had diabetes at baseline. The cumulative incidence of diabetes was 4.64% in 7 years and the raw incidence rate was 6.56 cases/1000 person-years (95%CI: 4.11-9.93). Among the incident cases, 59% were undiagnosed. The most strongly associated markers by univariate analyses were age >60 years, dyslipidaemia, prediabetes and insulin resistance. We also found association with hypertension, obesity, family history of diabetes and low education level. Multivariate analysis adjusted for age and sex showed that a set of risk factors assessed together (dyslipidaemia, waist-to-hip-ratio and family history of diabetes) had great predictive value (AUC-ROC=0.899, 95%CI: 0.846-0.953, p=0.942), which suggests the need for early intervention before the onset of prediabetes This work was partially supported by grants from the Department of Health of the Basque Country Government (2015111020); ISCIII (PI14/01104), co-funded by ERDF/ESF, "A way to make Europe"/"Investing in your future"; UPV/EHU (IT1281-19); Menarini Group Spain (BCA16/029); Endocrine-European Reference Network (EndoERN 739527); and CIBERDEM (Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders). The study funders were not involved in the design of the study; the collection, analysis, and interpretation of data; writing the report; and did not impose any restrictions regarding the publication of the report. |
| Databáze: | OpenAIRE |
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