Tracking white-matter brain modifications in chronic non-bothersome acoustic trauma tinnitus

Autor: Chloé Jaroszynski, Arnaud Attyé, Agnès Job, Chantal Delon-Martin
Rok vydání: 2021
Předmět:
AFD
Apparent Fiber Density
Audiology
IFO
Inferior Fronto-Occipital fasciculus
ILF
Inferior Longitudinal Fasciculus
Tinnitus
0302 clinical medicine
AF
Arcuate Fascicle
05 social sciences
Brain
Regular Article
16. Peace & justice
White Matter
Diffusion imaging
FX
fornix
Diffusion Tensor Imaging
medicine.anatomical_structure
Neurology
CC6
Corpus Callosum
isthmus part
medicine.symptom
Acoustic trauma tinnitus
Tractography
medicine.medical_specialty
ATR
Anterior Thalamic Radiations
Hearing loss
MNI
Montreal Neurological Institute
Cognitive Neuroscience
Computer applications to medicine. Medical informatics
R858-859.7
DTI
Diffusion Tensor Imaging
Uncinate fasciculus
FOD
Fiber Orientation Distribution
also known as fODF
fiber Orientation Density Function
050105 experimental psychology
Lateralization of brain function
White matter
03 medical and health sciences
Fractional anisotropy
otorhinolaryngologic diseases
medicine
Humans
0501 psychology and cognitive sciences
Radiology
Nuclear Medicine and imaging
Inferior longitudinal fasciculus
RC346-429
CA
Anterior Commissural bundle
ComputingMethodologies_COMPUTERGRAPHICS
HL
Hearing Loss
FA
Fractional Anisotropy
business.industry
Deep learning
DWI
Diffusion Weighted Imaging
CG
Cingulum
CSD
Constrained Spherical Deconvolution
CST
Cortico-Spinal Tract
Hearing Loss
Noise-Induced
FPT
Fronto-Pontine Tract
Anisotropy
HCP
Human Connectome Project
Neurology. Diseases of the nervous system
Neurology (clinical)
Constrained spherical deconvolution
business
030217 neurology & neurosurgery
Zdroj: NeuroImage: Clinical, Vol 31, Iss, Pp 102696-(2021)
NeuroImage : Clinical
ISSN: 2213-1582
DOI: 10.1016/j.nicl.2021.102696
Popis: Graphical abstract
Highlights • Tractography was compared between two groups of tinnitus and control participants. • Diffusion was modeled with ss3t-CSD allowing apparent fiber density (AFD) calculation. • 27 bundles of interest were chosen for their link to the auditory and limbic systems. • AFD was significantly increased in the tinnitus group in the right frontal isthmus. • AFD in the acoustic radiations was not significantly different between the groups.
Subjective tinnitus is a symptom characterized by the perception of sound with no external acoustic source, most often accompanied by co-morbidities. To date, the specific role of white matter abnormalities related to tinnitus reaches no consensus in the literature. The goal of this study was to explore the structural connectivity related to tinnitus percept per se, thus focusing on a specific population presenting chronic non-bothersome tinnitus of similar etiology (noise induced) without co-morbidities. We acquired diffusion-weighted images with high angular resolution in a homogeneous group of mildly impacted tinnitus participants (n = 19) and their matched controls (n = 19). We focused the study on two subsets of fiber bundles of interest: on one hand, we extracted the acoustic radiation and further included any intersecting fiber bundles; on the other hand, we explored the tracts related to the limbic system. We modeled the diffusion signal using constrained spherical deconvolution. We conducted a deep-learning based tractography segmentation and mapped Apparent Fiber Density (AFD) on the bundles of interest. C, as well as Fractional Anisotropy (FA) and FOD peak amplitude for comparison. Between group statistical comparison was performed along the 27 tracts of interest controlling for confounding hearing loss, tinnitus severity, and duration since onset. We tested a potential correlation with hearing loss, tinnitus duration and tinnitus handicap score along these tracts. In the tinnitus group, we observed increased AFD related to chronic tinnitus percept after acoustic trauma in two main white matter regions. First, in the right hemisphere, in the isthmus between inferior temporal and inferior frontal cortices, in the uncinate fasciculus (UF), and in the inferior fronto-occipital bundle (IFO). Second, in the left hemisphere, underneath the superior parietal region in the thalamo parietal tract and parieto-occipital pontine tract. Between-group differences in the acoustic radiations were not significant with AFD but were with FA. Furthermore, significant correlations with hearing loss were found in the left hemisphere in the inferior longitudinal fasciculus and in the fronto-pontine tract. No additional correlation was found with tinnitus duration nor with tinnitus handicap, as reflected by THI scores. The regions that displayed tinnitus related increased AFD also displayed increased FA. The isthmus of the UF and IFO in the right hemisphere appear to be involved with a number of neuropsychiatric and traumatic disorders confirming the involvement of the limbic system even in chronic non-bothersome tinnitus subjects, potentially suggesting a common pathway between these pathologies. White matter changes underneath the superior parietal cortex found here in tinnitus participants supports the implication of an auditory-somatosensory pathway in tinnitus perception.
Databáze: OpenAIRE
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