DETERMINATION OF DIAGNOSTIC ACCURACY OF BIOCHEMICAL PARAMETERS (CRP, LDH & FERRITIN) IN THE DIAGNOSIS OF COVID-19 IN SUSPECTED COVID CASES
| Autor: | Abdus Sattar, Aamir Ijaz, Tayyaba Ashiq, Sajida Shaheen, Qamar Bashir, Nasir Uddin |
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| Rok vydání: | 2021 |
| Předmět: |
Medicine (General)
medicine.medical_specialty Population Gastroenterology Asymptomatic law.invention chemistry.chemical_compound R5-920 c-reactive protein law Lactate dehydrogenase Internal medicine Medicine education Polymerase chain reaction education.field_of_study biology Receiver operating characteristic business.industry ferritin C-reactive protein lactate dehydrogenase Reverse transcriptase Ferritin covid-19 chemistry biology.protein diagnostic accuracy medicine.symptom business |
| Zdroj: | Pakistan Armed Forces Medical Journal, Vol 71, Iss 5, Pp 1722-1726 (2021) |
| ISSN: | 2411-8842 0030-9648 |
| Popis: | Objective: To determine the diagnostic accuracy of the Lactate Dehydrogenase, C-Reactive Protein and Ferritin in suspected patients of COVID-19. Study Design: Cross-sectional validation study. Place and Duration of Study: Pathology department of Combined Military Hospital Lahore in the month of May 2020. Methodology: We included 101 adult (>18 years) symptomatic suspected COVID-19 patients of both genders. Children, pregnant women and asymptomatic patients were excluded from study. Age, gender and results of Reverse Transcriptase Polymerase Chain Reaction, Lactate Dehydrogenase, C-Reactive Protein, ferritin were recorded. Results: Lactate Dehydrodenase had highest sensitivity (75%) with positive predictive value of 71.6% and diagnostic accuracy of 65.3% among three biochemical parameters studied. Receiver Operator Characteristic curve was studied. Area under curve of Lactate Dehydrogenase (AUC=0.65) and Ferritin (AUC=0.59) reflected their ability to prognosticate the presence of COVID19 disease. However, C-Reactive Protein (AUC=0.42) appeared to be a poor predictor of the disease. Conclusion: Raised serum Lactate Dehydrogenase (>490 U/L) and Ferritin (>152 ng/L) levels can be used to predict the Reverse Transcriptase Polymerase Chain Reaction positivity for COVID-19 in the population of suspected patients of COVID19. However, C-Reactive Protein is a poor predictor of COVID-19. |
| Databáze: | OpenAIRE |
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