Spatiotemporal refinement of signal flow through association cortex during learning
| Autor: | Ariel Gilad, Fritjof Helmchen |
|---|---|
| Přispěvatelé: | University of Zurich, Helmchen, Fritjof |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male medicine.medical_treatment General Physics and Astronomy Brain mapping Mice Discrimination Psychological 0302 clinical medicine Cortex (anatomy) 10064 Neuroscience Center Zurich lcsh:Science Brain Mapping 0303 health sciences Multidisciplinary Neocortex Behavior Animal 3100 General Physics and Astronomy medicine.anatomical_structure Sensory processing Whisker system Dorsum Science Auditory area 610 Medicine & health 1600 General Chemistry Motor Activity Biology Neural circuits General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences Task learning Calcium imaging 1300 General Biochemistry Genetics and Molecular Biology Biological neural network medicine Animals Learning Calcium Signaling Association (psychology) 030304 developmental biology 10242 Brain Research Institute General Chemistry Somatosensory Cortex Barrel cortex 030104 developmental biology 570 Life sciences biology lcsh:Q Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020) Nature Communications |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-020-15534-z |
| Popis: | Association areas in neocortex encode novel stimulus-outcome relationships, but the principles of their engagement during task learning remain elusive. Using chronic wide-field calcium imaging, we reveal two phases of spatiotemporal refinement of layer 2/3 cortical activity in mice learning whisker-based texture discrimination in the dark. Even before mice reach learning threshold, association cortex—including rostro-lateral (RL), posteromedial (PM), and retrosplenial dorsal (RD) areas—is generally suppressed early during trials (between auditory start cue and whisker-texture touch). As learning proceeds, a spatiotemporal activation sequence builds up, spreading from auditory areas to RL immediately before texture touch (whereas PM and RD remain suppressed) and continuing into barrel cortex, which eventually efficiently discriminates between textures. Additional correlation analysis substantiates this diverging learning-related refinement within association cortex. Our results indicate that a pre-learning phase of general suppression in association cortex precedes a learning-related phase of task-specific signal flow enhancement. Learning is a dynamic process involving many cortical areas. Here, using cortex-wide imaging, the authors show that in mice learning to discriminate between two textures a distinct task related signal flow is enhanced involving a specific association area whereas other association areas are suppressed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|