Differential cytokine network profile in polycythemia vera and secondary polycythemia
Autor: | Juçara Gastaldi Cominal, Natalia de Souza Nunes, Fabíola Attié de Castro, Maria Gabriela Berzoti-Coelho, Lúcia Helena Faccioli, Daniela Carlos, Lorena Lobo de Figueiredo-Pontes, Ítalo Sousa Pereira, Fabiani Gai Frantz, Maira da Costa Cacemiro, Raquel Tognon, Belinda Pinto Simões |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Male
0301 basic medicine Secondary Polycythemia medicine.medical_treatment lcsh:Medicine Disease Article Myeloproliferative disease 03 medical and health sciences 0302 clinical medicine Polycythemia vera medicine Humans Neoplastic transformation lcsh:Science Polycythemia Vera Aged Inflammation Multidisciplinary business.industry Interleukins lcsh:R medicine.disease Pathophysiology Haematopoiesis 030104 developmental biology Cytokine Case-Control Studies 030220 oncology & carcinogenesis Immunology Cytokines Female TROMBOSE lcsh:Q Stem cell business |
Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020) Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Scientific Reports |
ISSN: | 2045-2322 |
Popis: | Polycythemia vera (PV) is a clonal disorder resulting from neoplastic transformation of hematopoietic stem cells, while secondary polycythemia (SP) is a disease characterized by increased absolute red blood cell mass caused by stimulation of red blood cell production. Although the physiopathology of SP and PV is distinct, patients with these diseases share similar symptoms. The early differential diagnosis may improve the quality of life and decrease the disease burden in PV patients, as well as enable curative treatment for SP patients. PV is considered an oncoinflammatory disease because PV patients exhibit augmented levels of several pro-inflammatory cytokines. In this sense, we examined whether analysis of the cytokine production profile of SP and PV patients would help to distinguish them, despite their clinical similarities. Here we reported that SP patients exhibited decreased plasma levels of, IL-17A, IFN-γ, IL-12p70 and TNF-α when compared with PV patients, suggesting that analysis of the cytokine production profile may be an useful diagnostic biomarker to distinguish PV from SP patients. |
Databáze: | OpenAIRE |
Externí odkaz: | |
Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |