Differential cytokine network profile in polycythemia vera and secondary polycythemia

Autor: Juçara Gastaldi Cominal, Natalia de Souza Nunes, Fabíola Attié de Castro, Maria Gabriela Berzoti-Coelho, Lúcia Helena Faccioli, Daniela Carlos, Lorena Lobo de Figueiredo-Pontes, Ítalo Sousa Pereira, Fabiani Gai Frantz, Maira da Costa Cacemiro, Raquel Tognon, Belinda Pinto Simões
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Scientific Reports
ISSN: 2045-2322
Popis: Polycythemia vera (PV) is a clonal disorder resulting from neoplastic transformation of hematopoietic stem cells, while secondary polycythemia (SP) is a disease characterized by increased absolute red blood cell mass caused by stimulation of red blood cell production. Although the physiopathology of SP and PV is distinct, patients with these diseases share similar symptoms. The early differential diagnosis may improve the quality of life and decrease the disease burden in PV patients, as well as enable curative treatment for SP patients. PV is considered an oncoinflammatory disease because PV patients exhibit augmented levels of several pro-inflammatory cytokines. In this sense, we examined whether analysis of the cytokine production profile of SP and PV patients would help to distinguish them, despite their clinical similarities. Here we reported that SP patients exhibited decreased plasma levels of, IL-17A, IFN-γ, IL-12p70 and TNF-α when compared with PV patients, suggesting that analysis of the cytokine production profile may be an useful diagnostic biomarker to distinguish PV from SP patients.
Databáze: OpenAIRE
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