Three-dimensional analysis of tooth dimensions in the MSX1-missense mutation

Autor: L.M. Verhamme, Marie-José H. van den Boogaard, W.M.M. Fennis, Marco S. Cune, Carine Carels, Anne Marie Kuijpers-Jagtman, Thomas J.J. Maal, Marijn Créton
Přispěvatelé: Personalized Healthcare Technology (PHT)
Rok vydání: 2012
Předmět:
Male
SUPERNUMERARY TEETH
Molar
Three dimensional analysis
Dentistry
OLIGODONTIA
Crown dimensions
IMAGE-ANALYSIS SYSTEM
Odontometry
Missense mutation
Child
Netherlands
Orthodontics
HYPOHIDROTIC ECTODERMAL DYSPLASIA
Models
Dental
Incisor
medicine.anatomical_structure
TAURODONTISM
Mutation (genetic algorithm)
Female
Congenitally missing teeth
DENTAL AGENESIS
Adult
Taurodontism
Adolescent
3D analysis
GENETIC-BASIS
Mutation
Missense
INHERITED ANOMALIES
Biology
Statistics
Nonparametric
Young Adult
Imaging
Three-Dimensional
stomatognathic system
medicine
Humans
General Dentistry
Aged
Anodontia
MSX1 Transcription Factor
Tooth Crown
Analysis of Variance
Tooth Abnormalities
business.industry
Hypodontia
Dental Models
Evaluation of complex medical interventions Translational research [NCEBP 2]
medicine.disease
stomatognathic diseases
SIZE
Evaluation of complex medical interventions [NCEBP 2]
Case-Control Studies
Genetics and epigenetic pathways of disease Genomic disorders and inherited multi-system disorders [NCMLS 6]
business
MSX1
Zdroj: Clinical Oral Investigations, 17, 5, pp. 1437-45
Clinical Oral Investigations, 17(5), 1437-1445. SPRINGER HEIDELBERG
Clinical Oral Investigations, 17, 1437-45
ISSN: 1436-3771
1432-6981
DOI: 10.1007/s00784-012-0828-8
Popis: Item does not contain fulltext OBJECTIVES: A novel, 3D technique to measure the differences in tooth crown morphology between the MSX1 cases and non-affected controls was designed to get a better understanding of dental phenotype-genotype associations. MATERIALS AND METHODS: Eight Dutch subjects from a single family with tooth agenesis, all with an established nonsense mutation c.332 C > A, p. Ser 111 Stop in exon 1 of MSX1, were compared with unaffected controls regarding several aspects of tooth crown morphology of incisor and molar teeth. A novel method of quantitative three-dimensional analysis was used to detect differences. RESULTS: Statistically significant shape differences were observed for the maxillary incisor in the MSX1 family compared with the controls on the following parameters: surface area, buccolingual dimension, squareness, and crown volume (P
Databáze: OpenAIRE
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