Screening Metal Binding Selectivities of Macrocycle Mixtures by HPLC−ESI-MS and Postcolumn Reactions

Autor:	Jennifer S. Brodbelt, Dustin B. Farmer, Richard A. Bartsch, Michael T. Blanda, Esther C. Kempen
Rok vydání:	2000
Předmět:	chemistry.chemical_compound Electrospray Chromatography Hplc esi ms Chemistry Metal binding Organic solvent Calixarene Methanol Mass spectrometry High-performance liquid chromatography Analytical Chemistry
Zdroj:	Analytical Chemistry. 73:384-390
ISSN:	1520-6882 0003-2700
DOI:	10.1021/ac0010476
Popis:	A rapid method for the screening of metal binding selectivities of host compounds in mixtures is presented. This method involves the separation of mixtures of hosts by HPLC, followed by postcolumn complexation with one or more metals, then analysis by mass spectrometry. The intensities of the host-guest complexes in the mass spectra correlate with the binding selectivities of the hosts. The method was applied to a series of lariat ethers that were synthesized as ion-selective reagents for ion-selective electrodes. The compounds most selective for Na+ vs Li+ and K+ were identified. Additionally, a mixture of substituted calixarenes was screened for alkali-metal-binding selectivity. These compounds were determined to be selective for Cs+ over Rb+, K+, and Na+.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f242555ecf0a06729f95ceebffada88 https://doi.org/10.1021/ac0010476 Zobrazit plný text záznamu