Reduced striatal dopamine D2 receptors in people with Internet addiction
| Autor: | Sang Eun Kim, Sang Hyun Baik, Sungwon Choi, Sang Hee Kim, Chang-Soo Park, Su Jin Kim |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
media_common.quotation_subject education Caudate nucleus Striatum Young Adult Dopamine receptor D3 Dopamine receptor D2 mental disorders Humans Medicine media_common Raclopride Internet Receptors Dopamine D2 business.industry General Neuroscience Addiction Putamen Dopaminergic Magnetic Resonance Imaging Corpus Striatum Behavior Addictive Positron-Emission Tomography business Neuroscience medicine.drug |
| Zdroj: | NeuroReport. 22:407-411 |
| ISSN: | 0959-4965 |
| DOI: | 10.1097/wnr.0b013e328346e16e |
| Popis: | An increasing amount of research has suggested that Internet addiction is associated with abnormalities in the dopaminergic brain system. We hypothesized that Internet addiction would be associated with reduced levels of dopaminergic receptor availability in the striatum compared with controls. To test this hypothesis, a radiolabeled ligand [ 11 C]raclopride and positron emission tomography was used to assess dopamine D2 receptor binding potential in men with and without Internet addiction. Consistent with our prediction, individuals with Internet addiction showed reduced levels of dopamine D2 receptor availability in subdivisions of the striatum including the bilateral dorsal caudate and right putamen. This finding contributes to the understanding of neurobiological mechanism of Internet addiction. |
| Databáze: | OpenAIRE |
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