Antiallodynic interaction and motor performance of the pregabalin/thioctic acid and pregabalin/α-tocopherol combinations in neonatal streptozotocin-induced diabetic rats
| Autor: | Juan Carlos Huerta-Cruz, Francisco J. Flores-Murrieta, Lidia Elizabeth de la Cruz-Álvarez, Ángel Zúñiga-Romero, Juan Gerardo Reyes-García, Héctor I. Rocha-González, Claudia Ivonne Araiza-Saldaña |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Nervous system Side effect alpha-Tocopherol Pregabalin Pharmacology Antioxidants Diabetes Mellitus Experimental 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Drug Discovery medicine Animals Rats Wistar Analgesics Dose-Response Relationship Drug Thioctic Acid business.industry medicine.disease Streptozotocin Rats 030104 developmental biology Peripheral neuropathy Allodynia medicine.anatomical_structure Animals Newborn Hyperalgesia Drug Therapy Combination medicine.symptom business Psychomotor Performance 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Drug Development Research. 79:362-369 |
| ISSN: | 0272-4391 |
| DOI: | 10.1002/ddr.21473 |
| Popis: | Painful peripheral neuropathy can be associated with nerve damage caused by diabetes mellitus. Although pregabalin is the first-line therapy for peripheral neuropathy, it shows substantial discontinuation rates, mainly because of nervous system side effects as motor incoordination. Multimodal therapy may improve the motor side effect profile of pregabalin. The aim of this study was to evaluate the interaction of pregabalin + thioctic acid or pregabalin + α-tocopherol on allodynia and motor performance in neonatal streptozotocin-induced diabetic rats. Efficacy of drugs separately or in combination was tested by tactile allodynia using von Frey filaments. Isobolographic and interaction index analysis were used to determine the antiallodynic interaction between pregabalin and either thioctic acid or α-tocopherol. Motor performance was measured using a rotarod test. Pregabalin, thioctic acid, and α-tocopherol reduced, in a dose-dependent fashion, tactile allodynia. Pregabalin + thioctic acid and pregabalin + α-tocopherol combinations also dose-dependently reduced allodynic behavior in diabetic rats. Isobolographic analysis revealed an additive interaction for both combinations. Consistently, the interaction indices confirmed the additive effect between pregabalin + thioctic acid and pregabalin + α-tocopherol. In addition, the administration of either combination improved motor incoordination induced by pregabalin. Data suggests that thioctic acid or α-tocopherol could positively impact the therapeutic profile of pregabalin, because they might be useful for reducing motor incoordination associated to pregabalin in patients with peripheral neuropathy. |
| Databáze: | OpenAIRE |
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