The effect of iron nutritional status on Trypanosoma cruzi infection in germfree and conventional mice
| Autor: | Marcelo Eustáquio Silva, Leda Quercia Vieira, Jacques Robert Nicoli, Silva Me, Maria Lúcia Pedrosa, Márcio E. Silva, Eduardo Alves Bambirra, Enio C. Vieira |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Ratón Iron Nutritional Status Spleen Mice Inbred Strains Parasitemia Deferoxamine Leukocyte Count Mice Total iron-binding capacity Internal medicine medicine Animals Germ-Free Life Chagas Disease Trypanosoma cruzi chemistry.chemical_classification biology medicine.diagnostic_test Transferrin saturation General Medicine Iron Deficiencies medicine.disease biology.organism_classification medicine.anatomical_structure Endocrinology chemistry Immunoglobulin M Transferrin Immunoglobulin G Immunology Erythrocyte Count Protozoa Female Iron-Dextran Complex |
| Zdroj: | Repositório Institucional da UFOP Universidade Federal de Ouro Preto (UFOP) instacron:UFOP |
| Popis: | 1. 1. Conventional (CV) and gnotobiotic (GN) female CFW mice were infected with the Y strain of Trypanosoma cruzi. 2. 2. After infection, both CV and GN groups received injections of iron-dextran or desferrioxamine. Non-injected mice served as controls. 3. 3. The parasitemia was more intense in iron-dextran-treated mice. 4. 4. The iron levels in serum, liver, and spleen were: (a) not decreased by desferrioxamine and (b) increased by iron-dextran treatments. 5. 5. An increase in leukocyte numbers was observed in all GN and CV groups after infection. 6. 6. There was no difference in total iron binding capacity (TIBC) and iron saturation transferrin (IST) between GN and CV mice before infection. 7. 7. In CV groups, after infection, TIBC was decreased whereas the levels of IST were increased; in GN the opposite occurred. 8. 8. Trypanosome-specific IgG and IgM antibody levels were raised in the GN group but not in the CV group. |
| Databáze: | OpenAIRE |
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