Evaluation of Psoriasis Genetic Risk Based on Five Susceptibility Markers in a Population from Northern Poland
| Autor: | Lidia Cybulska, Ewa Kapińska, Joanna Wysocka, Krzysztof Rębała, Marta Stawczyk-Macieja, Roman Nowicki, Agnieszka Haraś, Aneta Szczerkowska-Dobosz, Paulina Miniszewska |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Population Immunology lcsh:Medicine Genome-wide association study Disease Biology Genetic Predisposition Autoimmune Diseases 03 medical and health sciences Psoriasis Genetic predisposition medicine Medicine and Health Sciences Genetics Genetics of the Immune System Genome-Wide Association Studies Allele lcsh:Science education education.field_of_study Evolutionary Biology Multidisciplinary Population Biology lcsh:R Biology and Life Sciences Computational Biology Human Genetics Odds ratio Genomics medicine.disease Genome Analysis Human genetics 030104 developmental biology Genetic Loci Genetics of Disease Genetic Polymorphism lcsh:Q Clinical Immunology Clinical Medicine Population Genetics Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 11, Iss 9, p e0163185 (2016) |
| ISSN: | 1932-6203 |
| Popis: | Psoriasis genetic background depends on polygenic and multifactorial mode of inheritance. As in other complex disorders, the estimation of the disease risk based on individual genetic variants is impossible. For this reason, recent investigations have been focused on combinations of known psoriasis susceptibility markers in order to improve the disease risk evaluation. Our aim was to compare psoriasis genetic risk score (GRS) for five susceptibility loci involved in the immunological response (HLA-C, ERAP1, ZAP70) and in the skin barrier function (LCE3, CSTA) between patients with chronic plaque psoriasis (n = 148) and the control group (n = 146). A significantly higher number of predisposing alleles was observed in patients with psoriasis in comparison to healthy individuals (6.1 vs. 5.2, respectively; P = 8.8×10-7). The statistical significance was even more profound when GRS weighted by logarithm odds ratios was evaluated (P = 9.9×10-14). Our results demonstrate the developed panel of five susceptibility loci to be more efficient in predicting psoriasis risk in the Polish population and to possess higher sensitivity and specificity for the disease than any of the markers analyzed separately, including the most informative HLA-C*06 allele. |
| Databáze: | OpenAIRE |
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