Divergent brainstem opioidergic pathways that coordinate breathing with pain and emotions

Autor: Shijia Liu, Mao Ye, Gerald M. Pao, Samuel M. Song, Jinho Jhang, Haibei Jiang, Jong-Hyun Kim, Sukjae J. Kang, Dong-Il Kim, Sung Han
Rok vydání: 2021
Předmět:
Zdroj: Neuron. 110(5)
ISSN: 1097-4199
Popis: Breathing can be heavily influenced by pain or internal emotional states, but the neural circuitry underlying this tight coordination is unknown. Here we report that Oprm1 (μ-opioid receptor)-expressing neurons in the lateral parabrachial nucleus (PBL) are crucial for coordinating breathing with affective pain in mice. Individual PBL
Databáze: OpenAIRE