Can the biliary enhancement of Gd-EOB-DTPA predict the degree of liver function?
| Autor: | Masayuki Kitano, Masatoshi Kudo, Tomoko Hyodo, Kazunari Ishii, Takamichi Murakami, Kazushi Numata, Seishi Kumano, Masahiro Okada |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Gadolinium DTPA Male medicine.medical_specialty Bilirubin Contrast Media Gd-EOB-DTPA Gastroenterology Excretion chemistry.chemical_compound Text mining Japan Liver Function Tests Predictive Value of Tests Internal medicine medicine Humans Infusions Intravenous Aged Aged 80 and over Analysis of Variance Hepatology medicine.diagnostic_test Bile duct business.industry Liver Neoplasms Magnetic resonance imaging Middle Aged Magnetic Resonance Imaging medicine.anatomical_structure Liver chemistry Female Bile Ducts Liver function Analysis of variance business Biomarkers Glomerular Filtration Rate |
| Zdroj: | Hepatobiliary & Pancreatic Diseases International. 11:307-313 |
| ISSN: | 1499-3872 |
| DOI: | 10.1016/s1499-3872(12)60165-9 |
| Popis: | Excretion of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) in the bile may be related to liver function, because of elimination from the liver after preferential uptake by hepatocytes. The purpose of this study was to investigate the relation between liver and biliary enhancement in patients with or without liver dysfunction, and to compare the tumor-to-liver contrast in these patients.Forty patients [group 1: normal liver and Child-Pugh class A in 20 patients, group 2: Child-Pugh class B in 18 patients and Child-Pugh C in 2] were evaluated. All patients underwent MR imaging of the liver using a 1.5-Tesla system. T1-weighted 3D images were obtained at 5, 10, 15 and 20 minutes after Gd-EOB-DTPA injection. The relation between group 3 (total bilirubin1.8 mg/dL) and group 4 (total bilirubin ≥1.8 mg/dL) was investigated at 20 minutes. Liver and biliary signals were measured, and compared between groups 1 and 2 or groups 3 and 4. Tumor-to-liver ratio was also evaluated between groups 1 and 2. Scheffe's post-hoc test after two-way repeated-measures ANOVA and Pearson's correlation test were used for statistical analysis.Liver enhancement showed significant difference at all time points between groups 1 and 2. Biliary enhancement did not show a significant difference between groups 1 and 2 at 5 minutes, but did at 10, 15 and 20 minutes. At 20 minutes, significant differences between groups 3 and 4 were seen for liver and biliary enhancement. At all time points, liver enhancement correlated with biliary enhancement in both groups. At 5 minutes and 20 minutes, statistical differences between groups 1 and 2 were seen for tumor-to-liver ratio.The degree of biliary enhancement has a close correlation to that of liver enhancement. It is especially important that insufficient liver enhancement causes lower tumor-to-liver contrast in the hepatobiliary phase of Gd-EOB-DTPA. |
| Databáze: | OpenAIRE |
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