Clinical implementation of 3D printing in the construction of patient specific bolus for electron beam radiotherapy for non-melanoma skin cancer

Autor: Rianne M. J. P. Gerritsen, Cornelia G. Verhoef, Marianne van Zeeland, Irene M. Lips, M. Kusters, Philip Poortmans, M. Wendling, R. Canters
Rok vydání: 2016
Předmět:
Male
Models
Anatomic
medicine.medical_specialty
Skin Neoplasms
3D printing
Electrons
030218 nuclear medicine & medical imaging
Workflow
Non-melanoma skin cancer
Bolus
03 medical and health sciences
Cancer development and immune defence Radboud Institute for Health Sciences [Radboudumc 2]
0302 clinical medicine
Electron beam radiotherapy
Planning study
medicine
Humans
Radiology
Nuclear Medicine and imaging
Medical physics
Radiation treatment planning
Aged
Aged
80 and over
business.industry
Radiotherapy Planning
Computer-Assisted
Radiotherapy Dosage
Hematology
Patient specific
Middle Aged
Clinical application
Women's cancers Radboud Institute for Health Sciences [Radboudumc 17]
Tissue equivalent
Oncology
030220 oncology & carcinogenesis
Printing
Three-Dimensional
Female
Nuclear medicine
business
Tomography
X-Ray Computed
Bolus (radiation therapy)
Non melanoma
Rare cancers Radboud Institute for Health Sciences [Radboudumc 9]
Zdroj: Radiotherapy and Oncology, 121, 1, pp. 148-153
Radiotherapy and Oncology, 121(1), 148-153. ELSEVIER IRELAND LTD
Radiotherapy and Oncology, 121, 148-153
ISSN: 0167-8140
Popis: Background and purpose: Creating an individualized tissue equivalent material build-up (i.e. bolus) for electron beam radiation therapy is complex and highly labour-intensive. We implemented a new clinical workflow in which 3D printing technology is used to create the bolus.Material and methods: A patient-specific bolus is designed in the treatment planning system (TPS) and a shell around it is created in the TPS. The shell is printed and subsequently filled with silicone rubber to make the bolus. Before clinical implementation we performed a planning study with 11 patients to evaluate the difference in tumour coverage between the designed 3D-print bolus and the clinically delivered plan with manually created bolus. For the first 15 clinical patients a second CT scan with the 3D-print bolus was performed to verify the geometrical accuracy.Results: The planning study showed that the V85% of the CTV was on average 97% (3D-print) vs 88% (conventional). Geometric comparison of the 3D-print bolus to the originally contoured bolus showed a high similarity (DSC = 0.89). The dose distributions on the second CT scan with the 3D print bolus in position showed only small differences in comparison to the original planning CT scan.Conclusions: The implemented workflow is feasible, patient friendly, safe, and results in high quality dose distributions. This new technique increases time efficiency. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
Databáze: OpenAIRE
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