Antineoplastic Agents, 177. Isolation and Structure of Phyllanthostatin 6
| Autor: | George R. Pettit, Ronald A. Nieman, Daniel E. Schaufelberger, Claude Dufresne, J. A. Saenz-Renauld |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Phyllanthus
Stereochemistry Pharmaceutical Science Phyllanthoside Pharmacognosy High-performance liquid chromatography Leukemia cell line Analytical Chemistry Mice Drug Discovery Botany Tumor Cells Cultured Animals Spiro Compounds Glycosides Chromatography High Pressure Liquid Benzofurans Pyrans Pharmacology chemistry.chemical_classification Phyllanthus acuminatus Molecular Structure biology Leukemia P388 Spectrum Analysis Organic Chemistry Euphorbiaceae Glycoside Plants biology.organism_classification Antineoplastic Agents Phytogenic Complementary and alternative medicine chemistry Molecular Medicine Sesquiterpenes |
| Zdroj: | Journal of Natural Products. 53:1406-1413 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np50072a002 |
| Popis: | The isolation and structural elucidation of a new Phyllanthus glycoside, phyllanthostatin 6 [7], was summarized. Phyllanthostatin 6 [7] was isolated from the roots of Phyllanthus acuminatus (Euphorbiaceae) and was found to inhibit (ED50 = 0.35 micrograms/ml) growth of the murine P-388 lymphocytic leukemia cell line. Two other new constituents were shown to be didesacetylphyllanthostatin 3 [9] and descinnamoylphyllanthocindiol [10]. Structure determinations were achieved employing hrfabms and 2D-nmr spectroscopy. Application of an hplc separation technique to the Phyllanthus glycosides and development of a new isolation procedure for the major antineoplastic constituent, phyllanthoside [1], are also described. |
| Databáze: | OpenAIRE |
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