Platelet activation by mercuric compounds

Autor:	Piotr Rieske, U. Krajewska, B. Kostka
Rok vydání:	1997
Předmět:	chemistry.chemical_element Hematology General Medicine Pharmacology Fibrinogen Blood proteins Mercury (element) chemistry Biochemistry Cell surface receptor Mole medicine Platelet Platelet activation Incubation medicine.drug
Zdroj:	Platelets. 8:413-418
ISSN:	1369-1635 0953-7104
Popis:	We previously showed that at low concentrations (0.01-10 micromol/l) mercury (Hg) compounds (especially methylmercuric chloride) may act synergistically with physiological agonists to activate platelets and may also cause changes in blood coagulation in experimental animals. Result obtained in this study indicate that the activation of pig blood platelets by methylmercuric chloride (MMC) is not dependent on membrane receptors for fibrinogen and ADP. Furthermore, we have calculated that pig platelets take up approximately 13-fold more Hg than plasma proteins during incubation of platelet-rich plasma with MMC. These findings may explain the recently reported link between vascular events and Hg poisoning.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f17135e5095f9cdce2fc55f4132c351 https://doi.org/10.1080/09537109777104 Zobrazit plný text záznamu