| Autor: |
Johannes H. Schulte, Esteban Cvitkovic, Angelika Eggert, Maria E. Riveiro, Lucile Astorgues-Xerri, Alexander Schramm, Natalie Sadowski, Sven Lindner, Kathy Astrahanseff, Annika Spruessel, Lukas Heukamp, Alexandra Florin, Katleen De Preter, Frank Westermann, Maike Nortmeyer, Emma Bell, Simon Schäfers, Frank Speleman, Richard Koche, Anneleen Beckers, Andrea Odersky, Kristina Althoff, Anton Henssen |
| Rok vydání: |
2023 |
| DOI: |
10.1158/1078-0432.22458708 |
| Popis: |
BET bromodomain inhibition leads to disruption of MYCN driven gene-expression programs even at high levels of MYCN. (a) Enrichment of the published gene expression signature for JQ1-treated human MYCN-amplified neuroblastoma cell lines (11) in differentially expressed genes in IMR-5 cells after treatment with OTX015, JQ1 or DMSO control. (b) Enrichment of the published gene expression signature for MYC target genes (16) in differentially expressed genes in IMR-5 cells after treatment with OTX015, JQ1 or DMSO control. (c) Enrichment of the published gene expression signature for JQ1-treated human MYCN-amplified neuroblastoma cell lines (11) in differentially expressed genes in mNB-A1 cells after treatment of with OTX015, JQ1 or DMSO control. (d) Enrichment of the published gene expression signature for MYC target genes (16) in differentially expressed genes in mNB-A1 cells after treatment with OTX015, JQ1 or DMSO control (* p < 0.05, ** p < 0.01, *** p < 0.001). (e) GSEA (version 2.0, Broad Institute) of differentially expressed genes in IMR5 cells after treatment with OTX015 or JQ1 using gene sets representing signatures of JQ1 as well as MYC target genes (11, 16). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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