Xanthones and Cancer: from Natural Sources to Mechanisms of Action
| Autor: | Adriana Rolim Campos, Rogério Corrêa, Luiz Carlos Klein-Júnior, Yvan Vander Heyden, Valdir Cechinel Filho, Rivaldo Niero |
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| Přispěvatelé: | Analytical Chemistry and Pharmaceutical Technology, Department of Analytical Chemistry, Applied Chemometrics and Molecular Modelling, Pharmaceutical and Pharmacological Sciences |
| Rok vydání: | 2020 |
| Předmět: |
Biological Products
DNA Repair 010405 organic chemistry Chemistry Xanthones Antineoplastic Agents Apoptosis Bioengineering Cell Cycle Checkpoints General Chemistry General Medicine Computational biology Plants 01 natural sciences Biochemistry 0104 chemical sciences 010404 medicinal & biomolecular chemistry Action (philosophy) Drug development Neoplasms Humans Molecular Medicine Molecular Biology |
| Zdroj: | Chemistry & Biodiversity. 17 |
| ISSN: | 1612-1880 1612-1872 |
| Popis: | Xanthones are a class of heterocyclic natural products that have been widely studied for their pharmacological potential. In fact, they have been serving as scaffolds for the design of derivatives focusing on drug development. One of the main study targets of xanthones is their anticancer activity. Several compounds belonging to this class have already demonstrated cytotoxic and antitumor effects, making it a promising group for further exploration. This review therefore focuses on recently published studies, emphasizing their natural and synthetic sources and describing the main mechanisms of action responsible for the anticancer effect of promising xanthones. |
| Databáze: | OpenAIRE |
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