Extensive white matter abnormalities associated with neonatal Parechovirus (HPeV) infection
| Autor: | Heinz Jungbluth, Sachin Gupta, Daphin Fernandez, Keith Pohl, William C.Y. Tong, Ata Siddiqui |
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| Rok vydání: | 2009 |
| Předmět: |
Pathology
medicine.medical_specialty Pediatrics Encephalopathy Parechovirus Biology Nerve Fibers Myelinated medicine Humans Brain Diseases Picornaviridae Infections Human parechovirus Infant Newborn Meningoencephalitis General Medicine medicine.disease biology.organism_classification Magnetic Resonance Imaging Pediatrics Perinatology and Child Health White matter abnormalities Female Neurology (clinical) Differential diagnosis Periventricular Leucomalacia Encephalitis Follow-Up Studies |
| Zdroj: | European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society. 14(6) |
| ISSN: | 1532-2130 |
| Popis: | White matter changes in the neonatal period are commonly associated with hypoxic-ischaemic injuries and, less frequently, infections. Enteroviral (EV) meningoencephalitis as a cause of extensive white matter changes in newborns is well documented but Human Parechovirus (HPeV) associated with a similar picture has only been recently recognized. We report a case of HPeV-related neonatal meningoencephalitis associated with extensive white matter abnormalities, giving rise to a wide differential diagnosis including consequences of hypoxic-ischaemic encephalopathy (HIE) and periventricular leucomalacia (PVL). This case highlights the importance of excluding both EV and HPeV infection in neonates presenting with signs and symptoms of encephalitis. Moreover, HPeV infection ought to be considered in infants with white matter changes suggestive of HIE but no convincing history of a perinatal hypoxic-ischaemic insult. |
| Databáze: | OpenAIRE |
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