Determination of the minor component bromhexine in cotrimoxazole-containing tablets by absorption spectrophotometry and partial least-squares (PLS-1) multivariate calibration
| Autor: | Ariana P. Pagani, María E. Ribone, Alejandro C. Olivieri |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Multivariate statistics
Bromhexina Chromatography medicine.diagnostic_test Absorption spectroscopy Chemistry Bromhexine Spectrophotometry Atomic Clinical Biochemistry Analytical chemistry Pharmaceutical Science Multivariate calibration Dosage form Analytical Chemistry Spectrophotometry Drug Discovery Partial least squares regression Calibration Trimethoprim Sulfamethoxazole Drug Combination medicine Least-Squares Analysis Spectroscopy medicine.drug Tablets |
| Zdroj: | Journal of pharmaceutical and biomedical analysis. 23(2-3) |
| ISSN: | 0731-7085 |
| Popis: | The mucolitic bromhexine [N-(2-amino-3,5-dibromobenzyl)-N-methylcyclohexylamine] has been determined in cotrimoxazole-containing tablets by partial least-squares (PLS-1) multivariate of spectrophotometric calibration data in the spectral range 310-350 nm. In the studied commercial tablets, cotrimoxazole is present in large excess (ca. 100:1 in weight) with respect to bromhexine, and a high degree of spectral overlapping exists among bromhexine and cotrimoxazole components. However, the obtained recoveries are reasonably good with the presently discussed technique. |
| Databáze: | OpenAIRE |
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