GRANULOMATOUS ENCEPHALOMYELITIS IN A FALSE GHARIAL (TOMISTOMA SCHLEGELII) ASSOCIATED WITH A NOVEL CHLAMYDIA SPECIES
| Autor: | Alexandra Goe, James F. X. Wellehan, Darryl J. Heard, Marjorie Bercier, Jeffrey R. Abbott, April L. Childress, E. D. Epperson |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Encephalomyelitis Biology law.invention 03 medical and health sciences law medicine Animals Chlamydia Polymerase chain reaction Phylogeny Alligators and Crocodiles General Veterinary Cerebrum Bayes Theorem General Medicine Amplicon Chlamydia Infections medicine.disease Spinal cord 030104 developmental biology medicine.anatomical_structure Gliosis Animal Science and Zoology Animals Zoo Female Brainstem medicine.symptom |
| Zdroj: | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 48(2) |
| ISSN: | 1042-7260 |
| Popis: | A 5-yr-old, captive, hatched, female false gharial (Tomistoma schlegelii) presented with a 1-mo history of cervical spinal curvature. Antemortem diagnostics, including blood work, electromyography, muscle biopsies, and advanced imaging tests, were either within reference ranges or did not identify any specific etiology. Necropsy revealed extensive, marked, chronic granulomatous encephalomyelitis along with neuronal necrosis, rarefaction, gliosis, and astrocytosis of the white and gray matter of the cerebrum, cerebellum, brainstem, and spinal cord. Pan-chlamydiae polymerase chain reaction protocols for the 16S ribosomal RNA and ompA genes were performed on samples of spinal cord and brain, and both resulted in amplicons. Sequencing of the products revealed that they were positive for a novel Chlamydia species. Infections by members of the phylum Chlamydiae have been reported in a diverse range of vertebrate hosts, including crocodilians. Chlamydia spp. infections are likely underdiagnosed because of a paucity of diagnostic techniques specific for detection. This is the first case report of a novel Chlamydia species associated with severe granulomatous encephalomyelitis in a false gharial. |
| Databáze: | OpenAIRE |
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