| Autor: |
Abdelrahman I. Abushouk, Ahmed Sayed, Malak Munir, Esraa Ghanem, Omar Abdelfattah, Erin D. Michos, Amgad Mentias, Samir Kapadia, Steven E. Nissen |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
American Journal of Preventive Medicine. 63:440-449 |
| ISSN: |
0749-3797 |
| Popis: |
This meta-analysis was performed to assess the efficacy of fixed-dose combination (polypill) in reducing the risk of mortality and cardiovascular events.Medline, Scopus, Web of Science, and Cochrane Central were searched during May 2021. All randomized trials investigating the efficacy of antihypertensive and lipid-lowering ± antiplatelet drug combinations in patients at cardiovascular risk were included. Outcomes were presented as risk ratios or standardized mean differences with 95% CIs.A total of 16 trials (N = 26,567 participants) were included. The risk reduction for all-cause mortality (risk ratio = 0.90; 95% CI = 0.79, 1.01; IDespite reductions in cardiovascular risk factors, the observed mortality benefit for the polypill did not reach statistical significance. Further studies are needed to validate its clinical benefits and determine the patient populations likely to achieve such benefits. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full Text from ScienceDirect