Traumatic brain injury as a risk factor for Alzheimer's disease: current knowledge and future directions
| Autor: | Kristen Dams-O'Connor, Gabrielle Guetta, Amanda E. Hahn-Ketter, Andrew Fedor |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Health Knowledge Attitudes Practice Biomedical Research Traumatic brain injury Poison control Disease 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Risk Factors Injury prevention Brain Injuries Traumatic Medicine Dementia Humans Risk factor Psychiatry business.industry Human factors and ergonomics medicine.disease nervous system diseases 030104 developmental biology Clinical research Nerve Degeneration Perspective Neurology (clinical) business 030217 neurology & neurosurgery Forecasting |
| Zdroj: | Neurodegenerative disease management. 6(5) |
| ISSN: | 1758-2032 |
| Popis: | There is growing concern about the late effects of traumatic brain injury (TBI). This scoping review summarizes clinical research from the past 10 years that evaluates the relationship between TBI and Alzheimer's disease. This review identified five studies that found increased risk for dementia after TBI, two studies that found no increased risk and four studies that found a relationship only under certain conditions or in specified subsamples. Methodological differences across studies preclude direct comparison of results, and discrepant findings elucidate the complex course of post-TBI neurodegeneration. We discuss the factors that influence the strength and direction of the relationship between TBI and Alzheimer's disease, and the implications of this body of research for patient care and future research. |
| Databáze: | OpenAIRE |
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