Insulin uptake by the human alcoholic cirrhotic liver
| Autor: | Karl-Ludvig Wiechel, Lars Sundblad, Nils Adner, Arne Nygren |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Cirrhotic liver Cirrhosis Metabolic Clearance Rate Biliary Tract Diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment Portal vein Gastroenterology Endocrinology Liver Cirrhosis Alcoholic Internal medicine medicine Hepatic extraction Humans Insulin Infusions Parenteral Vein Aged C-Peptide Portal Vein business.industry Middle Aged medicine.disease Constant rate infusion Peripheral Glucose medicine.anatomical_structure Liver Female business |
| Zdroj: | Metabolism. 34:48-52 |
| ISSN: | 0026-0495 |
| DOI: | 10.1016/0026-0495(85)90059-9 |
| Popis: | Insulin uptake by the human cirrhotic liver was studied in six patients with Laennec's cirrhosis, and the result was compared with that found in ten control patients with varying diseases affecting the biliary system. All patients had portal catheters for diagnostic purposes. The fractional hepatic uptake of insulin was calculated from the clearance rates for insulin obtained after a constant rate infusion into a peripheral vein and the portal vein in each patient. The fractional hepatic extraction of insulin was 13% +/- 5 in cirrhotic patients and differed significantly from the fractional hepatic extraction found in controls (51% +/- 5;P less than 0.001). |
| Databáze: | OpenAIRE |
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