Synthesis and Biodistribution of 1-[2-(cyclopentadienyltricarbonyltechnetium-99m)-2- oxo-ethoxy-phenyl]-1,2-di- (p-hydroxyphenyl)but-1-ene for tumor imaging
| Autor: | Tesnim Dallagi, Mouldi Saidi, Gerard Jaouen, Siden Top |
|---|---|
| Přispěvatelé: | Centre National des Sciences et Technologies Nucléaires [Tunisie] (CNSTN), Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL), Institut Parisien de Chimie Moléculaire (IPCM), Chimie Moléculaire de Paris Centre (FR 2769), Institut de Chimie du CNRS (INC)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Chimie du CNRS (INC)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Biodistribution
tumor Estrogen receptor [CHIM.THER]Chemical Sciences/Medicinal Chemistry 010402 general chemistry 01 natural sciences Biochemistry Inorganic Chemistry Breast cancer Materials Chemistry medicine 99m Tc radiolabelling [CHIM.COOR]Chemical Sciences/Coordination chemistry Physical and Theoretical Chemistry biodistribution Ene reaction Tumor imaging 010405 organic chemistry Chemistry tumor imaging Organic Chemistry Cancer medicine.disease 3. Good health 0104 chemical sciences SPECT Alkoxy group Cancer research High incidence |
| Zdroj: | Journal of Organometallic Chemistry Journal of Organometallic Chemistry, Elsevier, 2019, 591, pp.1-6. ⟨10.1016/j.jorganchem.2019.04.006⟩ |
| ISSN: | 0022-328X |
| DOI: | 10.1016/j.jorganchem.2019.04.006⟩ |
| Popis: | International audience; The high incidence and mortality of breast cancer and other estrogen receptor related tumors motivates efforts to develop innovative imaging probes to effectively diagnose, evaluate the extent of the tumor, and predict the efficacy of treatments while concurrently and selectively delivering anticancer agents to the cancer tissues. In the present study, 1-[2-(cyclopentadienyltricarbonyltechnetium-99m)-2-oxo-ethoxy-phenyl]-1,2-di-(p-hydroxyphenyl)but-1-ene was prepared and investigated as a potential agent for imaging estrogen receptors (ERs) in associated tumors. The compound was obtained in high 2 radiochemical purity and radiochemical yields. The biodistribution of the radioactive compound in mature female rats showed an ER-mediation in the ovarian target tissues as the uptake was reduced by a blocking dose of estradiol. The nonspecific uptake in muscle was relatively low. |
| Databáze: | OpenAIRE |
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