Chromosomal Localization of a Strain-Specific p53-Related Sequence in Rat (Rattus norvegicus)
| Autor: | Hiroshi Ikadai, Tomonori Imamichi, Tetsuo Kunieda, Eiji Kobayashi |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
DNA Complementary Genetic Linkage General Biochemistry Genetics and Molecular Biology Restriction fragment Species Specificity Genetic linkage Complementary DNA Animals Gene Southern blot Genetics General Veterinary biology Strain (biology) Chromosome Mapping Nucleic Acid Hybridization Chromosome Rats Inbred Strains DNA Restriction Enzymes General Medicine Genes p53 Molecular biology Rats Blotting Southern biology.protein Microsatellite Female Animal Science and Zoology |
| Zdroj: | Experimental Animals. 44:301-305 |
| ISSN: | 1881-7122 1341-1357 |
| DOI: | 10.1538/expanim.44.301 |
| Popis: | Strain-specific restriction fragments hybridizing to human p53 gene cDNA, which was detected in only particular strains of inbred rat were revealed by Southern blot hybridization of DNAs of various inbred rat strains. Chromosomal location of the strain-specific fragments was determined on rat chromosome 1 between Kal and Pkc loci by linkage analysis using microsatellite marker loci. The fragments were concluded to be a novel p53-related sequence which is present in particular rat strains and absent from the remaining strains. |
| Databáze: | OpenAIRE |
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