Endobronchial ultrasound-guided transbronchial needle aspiration can improve the diagnostic accuracy of positron emission tomography/computed tomography in hilar and/or mediastinal lymphadenopathy
| Autor: | Chuan-Cai Xu, Junhong Jiang, Chong-Jun Ni, Jian-An Huang, Zi-Rui Wang, Wei Lei |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Mediastinal lymphadenopathy Lymphadenopathy positron emission tomography/computed tomography Context (language use) Diagnostic accuracy lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine Positron Emission Tomography Computed Tomography endobronchial ultrasound-guided transbronchial needle aspiration medicine Humans Radiology Nuclear Medicine and imaging Lung cancer Endoscopic Ultrasound-Guided Fine Needle Aspiration Positron Emission Tomography-Computed Tomography medicine.diagnostic_test business.industry Incidence Mediastinum Reproducibility of Results General Medicine lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Quality Improvement lung cancer 030104 developmental biology Oncology Positron emission tomography Cytopathology 030220 oncology & carcinogenesis Female Histopathology Lymph Nodes Radiology business |
| Zdroj: | Journal of Cancer Research and Therapeutics, Vol 15, Iss 7, Pp 1490-1495 (2019) |
| ISSN: | 0973-1482 |
| DOI: | 10.4103/jcrt.jcrt_17_19 |
| Popis: | Context: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and positron emission tomography/computed tomography (PET/CT) are the two most extensively used methods for the diagnosis and staging of lung cancer. Aims: The present study was designed to compare the diagnostic performance of EBUS-TBNA with that of PET/CT in patients with hilar and/or mediastinal lymphadenopathy. Settings and Design: We compared the accuracy of EBUS-TBNA with that of PET/CT in the diagnosis of hilar and/or mediastinal lymphadenopathy and evaluated the diagnostic utility of EBUS-TBNA in patients with PET/CT false-positive and false-negative findings. Methods: This study retrospectively analyzed 85 patients with hilar and/or mediastinal lymphadenopathy who underwent EBUS-TBNA and PET/CT between January 2014 and December 2017. The accuracy of EBUS-TBNA histopathology and cytopathology was evaluated and compared with PET/CT scan findings. Results: The diagnostic accuracy of EBUS-TBNA combined with PET/CT was significantly higher than that of the single diagnostic method (P < 0.001). Among PET/CT-negative lymph nodes, 4 of 9 (44.4%) malignant lymph nodes were identified by EBUS-TBNA. Among PET/CT-positive lymph nodes, 43 of 47 (91.5%) benign lymph nodes were diagnosed by EBUS-TBNA. Conclusions: EBUS-TBNA combined with PET/CT could effectively reduce false-positive and false-negative rates in the diagnosis of hilar and mediastinal lymphadenopathy, which might provide accurate staging, determine optimum therapeutic strategy and improve survival in patients with lung cancer. |
| Databáze: | OpenAIRE |
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