Psoriasis confined strictly to vitiligo areas--a Koebner-like phenomenon?
| Autor: | N Bauer, TG Berger, Franklin Kiesewetter, Christian Maczek, Gerhard Schuler, M Lueftl, Miklós Simon |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Pathology medicine.medical_specialty T-Lymphocytes Population Vitiligo Dermatology medicine.disease_cause Autoimmunity Diagnosis Differential Psoriasis medicine Genetic predisposition Humans Genetic Predisposition to Disease education education.field_of_study business.industry ELISPOT Middle Aged medicine.disease Flow Cytometry Immunohistochemistry Granzyme B Infectious Diseases Immunology Female business CD8 |
| Zdroj: | Journal of the European Academy of Dermatology and Venereology : JEADV. 20(2) |
| ISSN: | 0926-9959 |
| Popis: | Vitiligo and psoriasis are both common skin disorders. However, psoriasis strictly confined to pre-existing vitiligo areas is rare and suggests a causal relationship. We report here on two patients with a strict anatomical colocalization of vitiligo and psoriasis. The histopathological examinations showed typical changes for both diseases together with a dense infiltrate of CD4+ and CD8+ T cells. By immunohistochemistry, intracytoplasmatic granzyme B and tumour necrosis factor alpha (TNF-alpha) were detected within the T-cell population, suggesting the functional activity of these cells and the creation of a local T helper 1 (Th1)-cytokine milieu. Additionally, in one patient we could identify anti-melanocytic T cells by tetramer staining and enzyme-linked immunospot (ELISPOT) analysis. These skin-infiltrating lymphocytes might trigger, by the local production of Th-1 cytokines such as TNF-alpha and interferon-gamma (IFN-gamma), the eruption of psoriatic plaques in patients with a genetic predisposition for psoriasis. |
| Databáze: | OpenAIRE |
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