Influence of the glutathione s-transferase gene polymorphisms on the susceptibility to basal cell skin carcinoma
| Autor: | Janaína Luisa Leite, Laura Sterian Ward, Ana Carolina Trindade Guilhen, Elaine Cristina Morari, Fabiana Granja, Gabriela M Campos |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Skin Neoplasms Genotype Biology Polymorphism genetic Chemical carcinogens medicine Humans Genetic Predisposition to Disease Basal Cell Skin Carcinoma Gene Carcinogen Aged Glutathione Transferase chemistry.chemical_classification Aged 80 and over Polymorphism Genetic integumentary system General Medicine Middle Aged medicine.disease Molecular biology Glutathione S-transferase Enzyme Biochemistry chemistry Glutathione S-Transferase pi Carcinoma Basal Cell biology.protein Carcinoma basal cell Female Skin cancer Epidemiologic Methods Reactive Oxygen Species Polymorphism Restriction Fragment Length |
| Zdroj: | Revista médica de Chile v.135 n.3 2007 SciELO Chile CONICYT Chile instacron:CONICYT |
| ISSN: | 0034-9887 |
| Popis: | Background: The identification of groups at high risk is fundamental to determine preventive strategies for skin cancer. Destructive reactive oxygen species produced by UVA or chemical carcinogens are metabolized by a series of enzymes. Polymorphisms of genes encoding for these enzymes may produce defective proteins with a diminished ability to detoxify a wide range of carcinogens. Aims: To ascertain the influence and potential interactions of several polymorphisms of genes encoding four important antioxidant GST enzymes in the susceptibility to cancer among Brazilians. Material and methods: We compared the genotypes of Glutathione S-Transferase mu, theta, pi and omega (GSTM1, GSTT1, GSTP1 and GSTO2) in a group of 102 patients with skin lesions and 124 controls. Results: Patients with Basal Cell Skin Carcinoma (BCC) presented the combined GSTM1-GSTT1+ genotype more frequently (49.1%) than controls (29.8%) (Fisher test; p =0.04), conferring a 2.273 (Odds Ratio; 95% CI =1.199-4.308) higher risk for BCC. We were not able to find any other association between genotypes or between any genotype and the patients' clinical features. Conclusions: The GST profile may help identify Brazilian individuals at higher risk for BCC |
| Databáze: | OpenAIRE |
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