Detecting motor unit abnormalities in amyotrophic lateral sclerosis using high-density surface EMG

Autor:	Yuichi Nishikawa, Aleš Holobar, Kohei Watanabe, Tetsuya Takahashi, Hiroki Ueno, Noriaki Maeda, Hirofumi Maruyama, Shinobu Tanaka, Allison S. Hyngstrom
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Motor Neurons Recruitment Neurophysiological electromyography Neurology motor unit recruitment Isometric Contraction Physiology (medical) Action Potentials Humans Neurology (clinical) Muscle Skeletal Amyotrophic lateral sclerosis Sensory Systems
Zdroj:	Clinical Neurophysiology. 142:262-272
ISSN:	1388-2457
Popis:	金沢大学理工研究域フロンティア工学系 ObjectiveThe purpose of this study was to detect specific motor unit (MU) abnormalities in people with amyotrophic lateral sclerosis (ALS) compared to controls using high-density surface electromyography (HD-SEMG).MethodsSixteen people with ALS and 16 control subjects. The participants performed ramp up and sustained contractions at 30% of their maximal voluntary contraction. HD-SEMG signals were recorded in the vastus lateralis muscle and decomposed into individual MU firing behavior using a convolution blind source separation method.ResultsIn total, 339 MUs were detected (people with ALS; n=93, control subjects; n=246). People with ALS showed significantly higher mean firing rate, recruitment threshold, coefficient of variation of the MU firing rate, MU firing rate at recruitment, and motoneurons excitability than those of control subjects (p Embargo Period 12 months
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f08a865c1ca2efa50f6d3efd63276a7 http://hdl.handle.net/2297/00066951 Zobrazit plný text záznamu Full Text from ScienceDirect