Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice

Autor:	Charles Z. Ding, Laurent Salphati, Hans E. Purkey, HongXiu Ge, Qin Yue, Antonio G. DiPasquale, Charles Eigenbrot, Qunh Ho, Kwong Wah Lai, Thomas O'Brien, Sharada Labadie, Zhongguo Chen, David A. Peterson, Shiva Malek, Laura Corson, Wenfeng Liu, Mark Ultsch, Jinhua Chen, Anna Hitz, Yajing Liu, Kirk Robarge, Jodie Pang, Chiho Li, Peter S. Dragovich, Binqing Wei, Shuguang Ma, Huihui Zhang, Steve Sideris, Zhenting Gao, Marie Evangelista, Ivana Yen, Aihe Zhou, Benjamin Fauber
Rok vydání:	2016
Předmět:	0301 basic medicine chemistry.chemical_classification Organic Chemistry Cell Biology Pharmacology Biochemistry Bioavailability 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Enzyme chemistry Cell culture 030220 oncology & carcinogenesis Lactate dehydrogenase Drug Discovery medicine Glycolysis IC50
Zdroj:	ACS Medicinal Chemistry Letters. 7:896-901
ISSN:	1948-5875
Popis:	A series of trisubstituted hydroxylactams was identified as potent enzymatic and cellular inhibitors of human lactate dehydrogenase A. Utilizing structure-based design and physical property optimization, multiple inhibitors were discovered with
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f0532bd0e9287d033f18781fd7cf755 https://doi.org/10.1021/acsmedchemlett.6b00190 Zobrazit plný text záznamu