Body Fat Parameters, Glucose and Lipid Profiles, and Thyroid Hormone Levels in Schizophrenia Patients with or without Metabolic Syndrome

Autor:	O.A. Lobacheva, Nikolay A. Bokhan, Viktoria V. Dubrovskaya, Elena G Kornetova, Arkadiy V. Semke, Anton J. M. Loonen, I. V. Tolmachev, Valeria I. Gerasimova, Irina A. Mednova, Alexander N. Kornetov, Svetlana A. Ivanova
Přispěvatelé:	PharmacoTherapy, -Epidemiology and -Economics, Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET)
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	medicine.medical_specialty Clinical Biochemistry visceral fat Article metabolic syndrome 03 medical and health sciences 0302 clinical medicine Internal medicine medicine General hospital Rank correlation lcsh:R5-920 business.industry Thyroid medicine.disease thyroid hormone 030227 psychiatry schizophrenia antipsychotics Endocrinology medicine.anatomical_structure Schizophrenia Thyroid hormones Free triiodothyronine biochemical parameters Metabolic syndrome business lcsh:Medicine (General) 030217 neurology & neurosurgery Hormone
Zdroj:	Diagnostics Diagnostics, 10(9):683. MDPI AG Diagnostics, Vol 10, Iss 683, p 683 (2020) Volume 10 Issue 9
ISSN:	2075-4418
Popis:	In this study, we aim to investigate associations between body fat parameters, glucose and lipid profiles, thyroid-stimulating hormone (TSH), and thyroid hormones (THs) levels in Tomsk-region schizophrenia patients depending upon the presence or absence of metabolic syndrome (MetS). A total of 156 psychiatric inpatients with schizophrenia who had been treated with antipsychotics for at least six months before entry were studied: 56 with and 100 without MetS. Reference groups consisted of general hospital inpatients with MetS and without schizophrenia (n = 35) and healthy individuals (n = 35). Statistical analyses were performed using the Mann&ndash Whitney U-test, chi-square test, Spearman&rsquo s rank correlation coefficient, multiple regression analyses, and descriptive statistics. Patients with schizophrenia and MetS had significantly higher levels of free triiodothyronine (FT3) and thyroxine (FT4) compared to schizophrenia patients without MetS (3.68 [3.25 5.50] vs. 3.24 [2.81 3.66], p = 0.0001, and 12.68 [10.73 15.54] vs. 10.81 [9.76 12.3], p = 0.0001, in pmol/L, respectively). FT3 maintained an association with MetS (p = 0.0001), sex (p = 0.0001), age (p = 0.022), and high-density lipoproteins (p = 0.033). FT4 maintained an association with MetS (p = 0.0001), sex (p = 0.001), age (p = 0.014), and glucose (p = 0.009). The data obtained showed body fat parameters, glucose and lipid profiles, and THs levels in Western-Siberian schizophrenia patients depending on MetS presence or absence.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f0513fcd414f42ac9748f7382e8650b https://doi.org/10.3390/diagnostics10090683 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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