Biodistribution of Amino-Functionalized Diamond Nanoparticles. In Vivo Studies Based on (18)F Radionuclide Emission
| Autor: | Deborah Pareto, J Raúl Herance, Santiago Rojas, Hermenegildo García, Victor M. Victor, Juan Domingo Gispert, Mercedes Alvaro, Sergio Abad, Roberto Martín, Cristina Menchón |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
Biodistribution Fluorine Radioisotopes Materials science Iron General Physics and Astronomy Nanoparticle In vivo evaluation Nanotechnology Spleen Nanodiamonds Rats Sprague-Dawley Surface-Active Agents QUIMICA ORGANICA Pulmonary surfactant Pharmacokinetics In vivo Surfactant medicine Animals General Materials Science Tissue Distribution Particle Size Rodent Radiochemistry General Engineering Biomaterial Hydrogen Peroxide Rats medicine.anatomical_structure PET Isotope Labeling Positron-Emission Tomography Fltration Particle size |
| Zdroj: | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia instname |
| DOI: | 10.1021/nn200986z |
| Popis: | [EN] Nanoparticles have been proposed for several biomedical applications; however, in vivo biodistribution studies to con¿rm their potential are scarce. Nanodiamonds are carbon nanoparticles that have been recently proposed as a promising biomaterial. In this study, we labeled nanodiamonds with 18F to study their in vivo biodistribution by positron emission tomography. Moreover, the impact on the biodistribution of their kinetic particle size and of the surfactant agents has been evaluated. Radiolabeled diamond nanoparticles accumulated mainly in the lung, spleen, and liver and were excreted into the urinary tract. The addition of surfactant agents did not lead to signi¿cant changes in this pattern, with the exception of a slight reduction in the urinary excretion rate. On the other hand, after ¿ltration of the radiolabeled diamond nanoparticles to remove those with a larger kinetic size, the uptake in the lung and spleen was completely inhibited and signi¿cantly reduced in the liver The present work was supported by Spanish MICINN (Grant CTQ-2009-11586); the Fondo de Investigacion Sanitaria (FIS) of the Instituto de Salud Carlos III (Grants PS09/02620, PI10/1195, and PS09/02217), La Marato TV3 Foundation (Grant 090530), and CDTI under the CENIT Programme (AMIT Project) and supported by the Spanish Ministry of Science and Innovation. R.M. thanks the Spanish Ministry for a postgraduate scholarship. V.M.V. is a recipient of Fond de Investigacion Sanitaria (FIS) and Generalitat Valenciana contract (CES10/030) |
| Databáze: | OpenAIRE |
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