Participation in and outcomes from a 12-month tailored exercise programme for people with multiple sclerosis (MSTEP©): a randomized trial
| Autor: | Ruth Barclay, Ross E. Andersen, Mark Bayley, Pierre Duquette, Yves Lapierre, Susan J. Bartlett, Kedar K.V. Mate, Ryan E.R. Reid, Nancy E. Mayo |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Multiple Sclerosis Patient Dropouts Physical Therapy Sports Therapy and Rehabilitation Physical function law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Humans Medicine Exercise Tolerance business.industry Multiple sclerosis Rehabilitation 030229 sport sciences Middle Aged Exercise capacity medicine.disease Exercise Therapy Exercise programme Treatment Outcome Quality of Life Physical therapy Patient Compliance Female business 030217 neurology & neurosurgery |
| Zdroj: | Clinical Rehabilitation. 34:927-937 |
| ISSN: | 1477-0873 0269-2155 |
| DOI: | 10.1177/0269215520923089 |
| Popis: | Objective: To estimate, among people with multiple sclerosis, the extent to which a personally tailored exercise programme (MSTEP©) resulted in greater improvements in exercise capacity and related outcomes over 12 months in comparison with general exercise guidelines. Design: Two-group randomized trial. Subjects: Ambulatory and sedentary. Interventions: MSTEP©, a personally adapted exercise regimen done on most days including two days of high intensity exercise; guidelines recommending 30 minutes of moderate intensity aerobic and strength training two times per week. Main measures: Primary outcome was peak oxygen consumption (VO2peak) at 12 months; secondary outcomes were composite measures of physical function, fatigue, and health-related quality of life. Results: In total, 137 people were randomized, 66 were lost over 12 months leaving 71 with outcome data, 34 in MSTEP© group, and 37 in the Guideline group. Exercise enjoyment and confidence and exercise-induced fatigue predicted retention. There were no differences between groups on the proportion making a 10% increase in VO2peak (27.1% MSTEP© vs 29.6% Guidelines; OR: 0.83; 95% CI: 0.23–3.08) by the 12 month assessment. The effect on fatigue was larger in the MSTEP© group than the Guideline groups (OR: 1.59; 95% CI: 0.93–2.74), the effect on physical function was more modest (OR: 1.35; 95% CI: 0.80–2.25), and null for health-related quality of life outcomes. Conclusions: The disappointing exercise retention suggests that people with multiple sclerosis may not consider exercise important to their brain health. Either type of exercise resulted in stable exercise capacity over 1 year in those sticking with the programme. |
| Databáze: | OpenAIRE |
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