Correlations between carotid IMT, factor VIII activity level and metabolic disturbances: a cardio-vascular risk factor in the HIV positive persons
| Autor: | Véronique Bellein, Luc de Saint Martin, S. Vallet, Luc Bressollette, Jérôme Duchemin, O. Vandhuick, Bertrand Arnaud, Elisabeth Pasquier |
|---|---|
| Přispěvatelé: | Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO), Département de Médecine Interne et Pneumologie [Brest] (DMIP - Brest), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), virology, Calvez, Ghislaine |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Male
Human immunodeficiency virus (HIV) HIV Infections 030204 cardiovascular system & hematology Carotid imt Vascular risk medicine.disease_cause MESH: Antiretroviral Therapy Highly Active 0302 clinical medicine Risk Factors MESH: Risk Factors Antiretroviral Therapy Highly Active 030212 general & internal medicine MESH: Anti-HIV Agents Ultrasonography [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology HIV-Associated Lipodystrophy Syndrome MESH: HIV Infections MESH: Factor VIII 3. Good health Venous thrombosis Infectious Diseases Carotid Arteries Cardiovascular Diseases Cardiology cardiovascular system Female Adult medicine.medical_specialty Anti-HIV Agents 03 medical and health sciences Virology Internal medicine medicine Humans cardiovascular diseases Thrombus MESH: HIV-Associated Lipodystrophy Syndrome Factor VIII MESH: Humans MESH: Carotid Arteries business.industry Surrogate endpoint MESH: Biological Markers MESH: Cardiovascular Diseases MESH: Adult Factor VIII Activity medicine.disease MESH: Male Immunology Metabolic syndrome business MESH: Female Biomarkers [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Zdroj: | Current HIV Research Current HIV Research, Bentham Science Publishers, 2007, 5 (3), pp.361-4 |
| ISSN: | 1570-162X |
| Popis: | International audience; In the HIV infection, the short time-scale between the HIV-induced cardiovascular events and the onset of antiretroviral therapy elicits a thrombophilic co-factor that worsens the induced atherosclerosis. We compared the factor VIII plasma activity, previously implicated in arterial and venous thrombosis, with a surrogate marker of atherosclerosis, the carotid intima-media thickness, and with the usual atherosclerosis risk factors in 154 HIV infected outpatients. The FVIII plasma activity is significantly associated with the carotid intima-media thickness and, strongly, with blood glucose and triglycerides levels. A raised FVIII plasma activity is an important feature of the metabolic syndrome and a putative co-factor of HAART induced cardiovascular events. Thus the prevention of the HAART-induced cardio-vascular events should probably not be exclusively focused on atherosclerosis but likewise on the thrombus formation process. |
| Databáze: | OpenAIRE |
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