Single-needle electroporation and interstitial electrochemotherapy: in vivo safety and efficacy evaluation of a new system

Autor: Markus Zimmermann, A. Ritter, Martin Liebl, Peter Isfort, Maximilian Schulze-Hagen, Christiane K. Kuhl, Federico Pedersoli, Ebba Dethlefsen, Joachim Georg Pfeffer, Philipp Bruners, Saskia von Stillfried
Rok vydání: 2019
Předmět:
Zdroj: European Radiology. 29:6300-6308
ISSN: 1432-1084
0938-7994
DOI: 10.1007/s00330-019-06251-3
Popis: We conducted an in vivo trial to investigate the safety and efficacy of a newly developed system for the application of a combined therapy consisting of irreversible electroporation (IRE) and electrochemotherapy (IRECT) in the liver. The system is conceived as a single-needle multitined applicator with expandable electrodes that allow interstitial injection of fluids, e.g., chemotherapy. Experiments were conducted in ten domestic pigs. The applicator was placed in different liver lobes under CT guidance. In one lobe, the applicator was used for conventional IRE (1500 V, 120 pulses, pulse length 100 μs). In the other lobe, the same procedure was performed preceded by the injection of a doxorubicin mixture through the expandable electrodes (IRECT). Contrast-enhanced CT and MRI were performed on days 1, 3, and 7 after the procedure. Accordingly, three animals were sacrificed on days 1, 3, and 7 after the imaging and ablation volumes were evaluated histopathologically. Related t test was used to compare the groups. Technical success was achieved in 9/10 experiments. One animal deceased during the intervention because of ventricular fibrillation. Follow-up CT 1 and 3 days after intervention showed a significant (p
Databáze: OpenAIRE
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